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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Carbocyclic Analogues of Distamycin and Netropsin

Author(s): Karolina Arciszewska, Anna Pućkowska, Agnieszka Wróbel and Danuta Drozdowska*

Volume 19, Issue 2, 2019

Page: [98 - 113] Pages: 16

DOI: 10.2174/1389557518666181009143203

Price: $65

Abstract

The DNA as the depository of genetic information is a natural target for chemotherapy. A lot of anticancer and antimicrobial agents derive their biological activity from their selective interaction with DNA in the minor groove and from their ability to interfere with biological processes such as enzyme catalysis, replication and transcription. The discovery of the details of minor groove binding drugs, such as netropsin and distamycin A, oligoamides built of 4-amino-1-methylpyrrole-2-carboxylic acid residues, allowed to develop various DNA sequence-reading molecules, named lexitropsins, capable of interacting with DNA precisely, strongly and with a high specificity, and at the same time exhibiting significant cytotoxic potential. Among such compounds, lexitropsins built of carbocyclic sixmembered aromatic rings occupy a quite prominent place in drug research. This work is an attempt to present current findings in the study of carbocyclic lexitropins, their structures, syntheses and biological investigations such as DNA-binding and antiproliferative activity.

Keywords: Distamycin, netropsin, minor groove binder, lexitropsin, carbocyclic analogue, anticancer drug, drug design.

Graphical Abstract

[1]
Remers, W.A.; Iyengar, B.S. Antitumor Antibiotics. in: Cancer chemotherapeutic agents,, (Ed. Foye W.O.), ACS, Washington, DC. 1995, 577-679
[2]
Finlay, A.C.; Hochstein, F.A.; Sobin, B.A.; Murphy, F.X. Netropsin, a new antibiotic produced by a Streptomyces. J. Am. Chem. Soc., 1951, 73, 341-343.
[3]
Arcamone, F.; Penco, F.; Orezzi, P.; Nicolella, V.; Pirelli, A. Structure and synthesis of distamycin A. Nature, 1964, 203, 1064-1065.
[4]
Krey, A.K.; Allison, R.G.; Hahn, F.E. Interactions of the antibiotic, distamycin A, with native DNA and with synthetic duplex polydeoxyribonucleotides. FEBS Lett., 1973, 29, 58-62.
[5]
Hahn, F.E. Distamycin A and netropsin. in: Mechanism of action of antimicrobial and antitumor agents;, Corcoran, J.W.; Hahn, F.E.; Shell, J.T.; Arrora, K.L. Antibiotics, Ed. Springer: Berlin, 1975; Vol. 3, pp. 79-100
[6]
Kopka, M.L.; Yoon, C.; Goodsell, D.; Pjura, P.; Dickerson, R.E. The molecular origin of DNA-drug specificity in netropsin and distamycin. Proc. Natl. Acad. Sci. USA, 1985, 82, 1376-1380.
[7]
Bailly, Ch.; Chaires, J.B. Sequence-specific DNA minor groove binders. Design and synthesis of netropsin and distamycin analogues. Bioconjugate . Chem., 1998, 9, 513-538.
[8]
Bourdouxhe-Housiaux, C.; Colson, P.; Houssier, C.; Waring, M.C.; Bailly, C. Interaction of a DNA-threading netropsin-amsacrine combilexin with DNA and chromatin. Biochemistry, 1996, 35, 4251-4264.
[9]
Cozzi, P.; Monelli, N.; Suarato, A. Recent anticancer cytotoxic agents. Curr. Med. Chem. - Anti-Cancer Agents, 2004, 4, 93-121.
[10]
Berman, H.M.; Neidle, S.; Zimmer, C.; Thrum, H. Netropsin, a DNA-binding oligopeptide structural and binding studies. Biochim. Biophys. Acta, 1979, 561, 124-131.
[11]
Gurskaya, G.V.; Grohovsky, S.L.; Zhuze, A.L.; Gottich, B.P. DNA-binding antibiotics X-ray structure of the distamycin A analogue. Biochim. Biophys. Acta, 1979, 563, 336-342.
[12]
Luck, G.; Zimmer, C.; Reinert, K.E.; Arcamone, F. Specific interactions of distamycin A and its analogs with (A-T) rich and (G-C) rich duplex regions of DNA and deoxypolynucleotides. Nucleic Acids Res., 1977, 4, 2655-2670.
[13]
Wemmer, D.E.; Dervan, P.B. Targeting the minor groove of DNA. Curr. Opin. Struct. Biol., 1997, 7, 355-361.
[14]
Sondhi, S.M.; Praveen Reddy, B.S.; Lown, J.W. Lexitropsin conjugates: Action on DNA targets. Curr. Med. Chem., 1997, 4, 313-358.
[15]
Pindur, U.; Jansen, M.; Lemster, T. Advances in DNA-ligands with groove binding, intercalating and/or alkylating activity: chemistry, DNA-binding and biology. Curr. Med. Chem., 2005, 12, 2805-2847.
[16]
Khan, G.S.; Shah, A.; Rehman, Z.; Baker, D. Chemistry of DNA minor groove binding agents. J. Photochem. Photobiol. B Biol, 2012, 115, 105-118.
[17]
Bartulewicz, D.; Bielawski, K.; Krajewska, D.; Różański, A. Synthetic analogues of netropsin and distamycin. II. Synthesis of a carbocyclic analogue of the pyrrolecarboxamide antitumour antibiotics. Ann. Acad. Med. Bialos., 1995, 40, 364-375.
[18]
Turner, P.R.; Ferguson, L.R.; Denny, A. Polybenzamide mustards: structure-activity relationships for DNA sequence-specific alkylation. Anti-Cancer Drug Des., 1999, 14, 61-70.
[19]
Bialer, M.; Yagen, B.; Mechoulam, R. A total synthesis of distamycin a, an antiviral antibiotic. Tetrahedron, 1978, 34, 2389-2391.
[20]
Rajagopalan, M.; Rao, K.E.; Ayyer, J.; Sasisekharan, V. Synthesis of a distamycin analogue: Tris(m-benzamido) compound. Ind J. Chem., 1987, 26B, 1021-1024.
[21]
Rajagopalan, M.; Sasisekharan, V. Interaction of non-intercalative drugs with DNA: distamycin analogues. J. Biosci., 1985, 7, 27-32.
[22]
Dasgupta, D.; Rajagopalan, M.; Sasisekharan, V. DNA-binding characteristics of a synthetic analogue of distamycin. Biochem. Biophys. Res. Commun., 1986, 140, 626-631.
[23]
Rao, K.E.; Sasisekharan, V. Synthesis of distamycin and netropsin analogs: Part III - Biologically active analogs of tris(m-benzamido)compound. Ind J. Chem., 1990, 29B, 508-513.
[24]
Arya, D.P.; Warner, P.M.; Jebaratnam, D.J. Development of new DNA-binding and cleaving molecules: Design, synthesis and activity of a bisdiazonium salt. Tetrahedron Lett., 1993, 34, 7823-7826.
[25]
Yan, Y.; Liu, M.; Gong, B. Two-ring DNA minor-groove binders consisting of readily available di-substituted benzene derivatives. Bioorg. Med. Chem. Lett., 1997, 7, 1469-1474.
[26]
Gong, B.; Yan, Y. New DNA minor-groove binding molecules with high sequence-selectivities and binding affinities. Biochem. Biophys. Res. Com., 1997, 240, 557-560.
[27]
Bartulewicz, D.; Bielawski, K.; Markowska, A.; Zwierz, K.; Pućkowska, A.; Różański, A. Synthetic analogues of netropsin and distamycin - synthesis of a new pyridine and carbocyclic analogues of the pyrrolecarboxamide antitumour antibiotics. Acta Biochim. Polon., 1998, 45, 41-57.
[28]
Bartulewicz, D.; Markowska, A.; Wołczyński, S.; Dąbrowska, M.; Różański, A. Molecular modelling, synthesis and antitumour activity of carbocyclic analogues of netropsin and distamycin - new carriers of alkylating elements. Acta Biochim. Polon., 2000, 47, 23-35.
[29]
Bielawski, K.; Bielawska, A.; Bartulewicz, D.; Różański, A. Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d[CGCGAATTCGCG]2. Acta Biochim. Polon., 2000, 47, 855-866.
[30]
Pućkowska, A.; Bielawski, K.; Bielawska, A.; Różański, A. New carbocyclic analogues of netropsin: Synthesis and inhibition of topoisomerases. Acta Biochim. Pol., 2002, 49, 177-183.
[31]
Bartulewicz, D.; Bielawski, K.; Bielawska, A. Carbocyclic analogues of netropsin and distamycin: DNA-binding properties and inhibition of DNA topoisomerases. Arch. Pharm. Med. Chem, 2002, 9, 422-426.
[32]
Pućkowska, A.; Drozdowska, D.; Midura-Nowaczek, K. Carbocyclic analogues of lexitropsin - DNA affinity and endonuclease inhibition. Acta Polon. Pharm., 2007, 64, 115-119.
[33]
Pućkowska, A.; Midura-Nowaczek, K.; Bruzgo, I. Effects of netropsin and pentamidine amino analogues on the amidolytic activity of plasmin, trypsin and urokinase. Acta Polon. Pharm., 2008, 65, 213-215.
[34]
König, B.; Papke, U.; Rödel, M. Synthesis of aromatic and heteroaromatic oligoamides on methoxypoly(ethylene glycol) as solubilizing polymer support. New J. Chem., 2000, 24, 39-45.
[35]
Drozdowska, D. New solid phase synthesis of distamycin analogues. Molecules, 2011, 16, 3066-3076.
[36]
Drozdowska, D.; Szerszenowicz, J. Semi-automatic synthesis of distamycin analogues and their DNA-binding properties. Lett. Drug Des. Discov., 2012, 9, 12-16.
[37]
Drozdowska, D.; Rusak, M.; Miltyk, W.; Markowska, A.; Samczuk, P. Antiproliferative effects on breast cancer cells and some interactions of new distamycin analogues wit DNA, endonucleases and DNA topoisomerases. Acta Polon. Pharm., 2016, 73, 47-53.
[38]
Arcamone, F.; Lazzari, E.; Menozzi, M.; Sornzo, C.; Verini, M.A. Synthesis, DNA binding and antiviral activity of distamycin analogues containing different heterocyclic moieties. Anticancer Drug Des., 1986, 1, 235-244.
[39]
Kӧnig, B.; Rӧdel, M. Synthesis of DNA-binding heteroaromatic oligoamides on liquid solid support. Chem. Commun., 1998, 605-606.
[40]
Dudouit, F.; Goossens, J.F.; Houssin, R.; Henichart, J.P.; Colson, P.; Houssier, C.; Gelus, N.; Bailly, C. Synthesis, DNA binding, topoisomerases inhibition and cytotoxic properties of 4-Arylcarboxamidopyrrolo-2-carboxyanilides. Bioorg. Med. Chem. Lett., 2000, 10, 553-557.
[41]
Boger, D.L.; Dechantsreiter, M.A.; Ishii, T.; Fink, B.E.; Hedrick, M.P. Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents. Bioorg. Med. Chem., 2000, 8, 2049-2057.
[42]
Boger, D.L.; Fink, B.E.; Hedrick, M.P. Total synthesis of distamycin A and 2640 analogues: a solution-phase combinatorial approach to the discovery of new, bioactive DNA binding agents and development of a rapid, high-throughput screen for determining relative DNA binding affinity or DNA binding sequence selectivity. J. Am. Chem. Soc., 2000, 122, 6382-6394.
[43]
Hu, W.; Bȕrli, R.W.; Kaizerman, J.A.; Johnson, K.W.; Gross, M.I.; Iwamoto, M.; Jones, P.; Lofland, D.; Difuntorum, S.; Chen, H.; Bozdogan, B.; Appelbaum, P.C.; Moser, H.E. DNA binding ligands with improved in vitro and in vivo potency against drug-resistant Staphylococcus aureus. J. Med. Chem., 2004, 47, 4352-4355.
[44]
Anthony, N.G.; Breen, D.; Clarke, J.; Donoghue, G.; Drummond, A.J.; Ellis, E.M.; Gemmell, C.G.; Helesbeux, J.J.; Hunter, I.S.; Khalaf, A.I.; Mackay, S.P.; Parkinson, J.A.; Suckling, C.J.; Waigh, R.D. Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups. J. Med. Chem., 2007, 50, 6116-6125.
[45]
Brucoli, F.; Howard, P.W.; Thurston, D.E. Efficient solid-phase synthesis of a library of distamycin analogs containing novel biaryl motifs on SynPhase Lanterns. J. Comb. Chem., 2009, 11, 576-586.
[46]
Drozdowska, D.; Rusak, M.; Bielawski, T.; Midura-Nowaczek, K. Analogues of distamycin -- synthesis and biological evaluation of new aromatic oligopeptides, potential anticancer agents. Acta Polon. Pharm., 2009, 66, 633-638.
[47]
Drozdowska, D.; Bruzgo, I.; Midura-Nowaczek, K. Carbocyclic potential DNA minor groove binders and their biological evaluation. J. Enz Inhib. Med. Chem., 2010, 25, 629-634.
[48]
Drozdowska, D.; Rusak, M.; Miltyk, W.; Midura-Nowaczek, K. Synthesis and biological evaluation of distamycin analogues - new potential anticancer agents. Arch. Pharm. Chem. Life Sci., 2009, 342, 87-93.
[49]
Szerszenowicz, J.; Drozdowska, D. Semi-automatic synthesis, antiproliferative activity and DNA-binding properties of new netropsin and bis-netropsin analogues. Molecules, 2014, 11300-11315.
[50]
Lown, J.W. Lexitropsins: rational design of DNA sequence reading agents as novel anti-cancer agents and potential cellular probes. Anticancer Drug Des., 1988, 3, 25-40.
[51]
Walker, W.L.; Kopka, M.L.; Goodsell, D.S. Progress in the design of DNA sequence-specific lexitropsins. Biopolymers, 1997, 44, 323-334.
[52]
Neamati, N.; Mazumder, A.; Sunder, S.; Owen, J.M.; Tandon, M.; Lown, J.W.; Pommier, Y. Highly potent synthetic polyamides, bisdistamycins, and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase. Mol. Pharmacol., 1998, 54, 280-290.
[53]
Pućkowska, A.; Bielawski, K.; Bielawska, A.; Midura-Nowaczek, K. Aromatic analogues of DNA minor groove binders - synthesis and biological evaluation. Eur. J. Med. Chem., 2004, 39, 99-105.
[54]
Bartulewicz, D.; Anchim, T.; Dąbrowska, M.; Midura-Nowaczek, K. Synthesis and cytotoxic effect of carbocyclic potential minor groove binders. Farmaco, 2004, 59, 211-214.
[55]
Ali, A.; Bhattacharya, S. DNA binders in clinical trials and chemotherapy. Bioorg. Med. Chem., 2014, 22, 4506-4521.
[56]
Broggini, M.; Coley, H.M.; Mongelli, N.; Presenti, E.; Wyatt, M.D.; Hartley, J.A.; D’Incalci, M. DNA sequence-specific adenine alkylation by the novel anti-tumour drug Tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin. Nucleic Res., 1995, 23, 81-87.
[57]
Broggini, M.; Marchini, S.; Fontana, E.; Moneta, D.; Fowst, C.; Geroni, C. Brostallicin: a new concept in minor groove DNA binder development. Anticancer Drugs, 2004, 15, 1-6.
[58]
Baraldi, P.G.; Cacciari, B.; Guiotto, A.; Leoni, A.; Romagnoli, R.; Spalluto, G.; Mongelli, N.; Howard, P.W.; Thurston, D.E.; Bianchi, N.; Gambari, R. Design, synthesis and biological activity of a pyrrolo [2, 1- c][1,4]benzodiazepine (PBD)-distamycin hybrid. Bioorg. Med. Chem. Lett., 1998, 8, 3019-3024.
[59]
Baraldi, P.G.; Cacciarit, B.; Guiotto, A.; Romagnoli, R.; Spalluto, G.; Leoni, A.; Bianchi, N.; Feriotto, G.; Rutigliano, C.; Mischiati, C.; Gambari, R. [1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding to transcription factor Sp1. Nucleos. Nucleot. Nucl., 2000, 19, 1219-1229.
[60]
Gelderblom, H.; Blay, J.Y.; Seddon, B.M.; Leahy, M.; Ray-Coquard, I.; Sleijfer, S.; Kerst, J.M.; Rutkowski, P.; Bauer, S.; Ouali, M.; Marreaud, S.; van der Straaten, R.J.H.M.; Guchelaar, H.J. Weitman SD1, Hogendoorn, P.C.V.; Hohenberger, P. Brostallicin versus doxorubicin as first-line chemotherapy in patients with advanced or metastatic soft tissue sarcoma: An european organisation for research and treatment of cancer soft tissue and bone sarcoma group randomised phase II and pharmacogenetic study. Eur. J. Cancer, 2014, 50, 388-396.
[61]
Markowska, A.; Bartulewicz, D.; Pućkowska, A.; Różański, A. Synthetic analogues of netropsin and distamycin. 4.Synthesis of a new carbocyclic analogue of distamycin with alkylating side groups. Ann. Acad. Med. Bialos., 1997, 42, 129-140.
[62]
Baker, B.F.; Dervan, P.B. Sequence-specific cleavage of DNA by N-bromoacetyldistamycin. Product and kinetic analyses. J. Am. Chem. Soc., 1989, 111, 2700-2712.
[63]
Watts, C.R.; Kerwin, S.M.; Kenyon, G.L.; Kuntz, I.D.; Kallick, D.A. Rationally designed N,N′-Bis[(N-p-guanidinobenzyl-N-methyl)aminocarbonyl]-1,3-diaminobenzene, “BIGBEN’, binds to the minor groove of d(CGCGAATTCGCG)2 as determined by two-dimensional nuclear magnetic resonance spectroscopy. J. Am. Chem. Soc., 1995, 117, 9941-9950.
[64]
Markowska, A.; Różański, A. Synthetic analogues of netropsin and distamycin. VI. Synthesis of carbocyclic lexitropsins containing A bioreductive element. Acta Polon. Pharm., 2000, 57, 71-76.
[65]
Markowska, A.; Różański, A.; Wołczyński, S.; Midura-Nowaczek, K. Synthesis and biological activity of carbocyclic lexitropsins with a bioreductive fragment. Farmaco, 2002, 57, 1019-1023.
[66]
Bartulewicz, D.; Bielawski, K.; Bielawska, A.; Różański, A. Synthesis, molecular modelling, and antiproliferative and cytotoxic effects of carbocyclic derivatives of distamycin with chlorambucil moiety. Eur. J. Med. Chem., 2001, 36, 461-467.
[67]
Bartulewicz, D. Aromatic oligopeptides with chlorambucil moiety - synthesis and biological evaluation. Acta Polon. Pharm., 2005, 62, 451-455.
[68]
Pućkowska, A.; Bartulewicz, D.; Markowska, A.; Różański, A. Synthesis of a carbocyclic bis-lexitropsin as DNA cleaving agent. Acta Polon. Pharm., 1999, 56, 104-111.
[69]
Pućkowska, A.; Bartulewicz, D.; Midura-Nowaczek, K. Aromatic benzotriazole amides - synthesis and biological evaluation. Acta Polon. Pharm., 2005, 62, 59-64.
[70]
Barret, M.P.; Gemmell, C.G.; Suckling, C.J. Minor groove binders as anti-infective agents. Pharmacol. Ther., 2012, 139, 12-23.

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      • 4: 316870080
      • 5: 316870080
      • 6: 316870080
      • 7: 316870080
      • 8: 316870080
      • 9: 316870080
      • 10: 316870080
      • 11: 316870080
      • 12: 316870080
      • 13: 316870080
      • 14: 316870080
      • 15: 316870080
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=93558
      760μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 56 limit 1
      1.08msalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 56
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=56) and sj.journal_id!=56 group by `j`.`nid`) as `aggregate_table`
      1.61msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=56) and sj.journal_id!=56 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      1.27msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=56) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      1.98msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=56) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.82msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '93558'
      320μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 93558
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '93558'
      3.08msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 93558
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '93558' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      2.6msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 93558
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      280μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      630μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 56 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      44.69msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 56 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      13.53msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 56 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      12.73msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 93558 limit 1
      210μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 93558
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 93558 and content_type = 'article' order by status desc limit 1
      280μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid article_nid,a.title article_title,j.title journal_title from content_by_diseases cd inner join article a on a.article_id=cd.content_id inner join journal j on j.journal_id=a.journal_id where cd.pid = 281 and cd.sub_disease_id = 297 and content_id!=93558 and cd.content_type = 'article' order by rand() limit 20
      144msalphaeurekaselec_live_10_06_2022Article.php#769
      Backtrace
      • 11. app/Models/Article.php:769
      • 12. app/Http/Controllers/ArticleController.php:2098
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 166096 limit 1
      260μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 166096
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      250μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'MRMC' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      330μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: MRMC
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '93558' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      330μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '8768' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      280μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '2608' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      240μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316870080 and j.to_ip >=316870080 )) and ((j.from_date <= 1740344786 and j.to_date >= 1740344786 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2608) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316870080 and j.to_ip >=316870080 )) and ((j.from_date <= 1740344786 and j.to_date >= 1740344786 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2608) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316870080 and j.to_ip >=316870080 )) and ((j.from_date <= 1740344786 and j.to_date >= 1740344786 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2608)
      5.71msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316870080 and j.to_ip >=316870080 )) and ((j.from_date <= 1740344786 and j.to_date >= 1740344786 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 8768) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316870080 and j.to_ip >=316870080 )) and ((j.from_date <= 1740344786 and j.to_date >= 1740344786 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 8768) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316870080 and j.to_ip >=316870080 )) and ((j.from_date <= 1740344786 and j.to_date >= 1740344786 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 8768)
      570μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316870080 and j.to_ip >=316870080 )) and ((j.from_date <= 1740344786 and j.to_date >= 1740344786 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 93558) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316870080 and j.to_ip >=316870080 )) and ((j.from_date <= 1740344786 and j.to_date >= 1740344786 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 93558) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316870080 and j.to_ip >=316870080 )) and ((j.from_date <= 1740344786 and j.to_date >= 1740344786 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 93558)
      550μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '98' and is_uploaded = 1 and issue_id = 8768 order by cast(first_page as SIGNED) desc limit 1
      440μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 98
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '113' and is_uploaded = 1 and issue_id = 8768 order by cast(first_page as SIGNED) asc limit 1
      370μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 113
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      230μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      250μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 93558 limit 1
      3.21msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 93558
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 56 and `b`.`banner_from_date` <= 1740344786 and `b`.`banner_to_date` >= 1740344786 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.59msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 56
      • 3: 1740344786
      • 4: 1740344786
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 56 and `b`.`banner_from_date` <= 1740344786 and `b`.`banner_to_date` >= 1740344786 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.39msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 56
      • 3: 1740344786
      • 4: 1740344786
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='279154a38662aba02ee246160d5c1cf0'
      230μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
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        array:1 [ "url" => "http://alpha.eurekaselect.com/article/93558" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
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        []
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        status_code
        200
        
        status_text
        OK
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        request_headers
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        ClearShow all
        Date ↕MethodURLData
        #12025-02-23 21:06:26GET/article/93558314371