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Review Article

呼出气冷凝物的代谢组学：核磁共振波谱和质谱：方法论

卷 27, 期 14, 2020

页: [2381 - 2399] 页: 19

弟呕挨: 10.2174/0929867325666181008122749

价格: $65

摘要

呼吸系统疾病在普通人群中的流行率很高，全世界的发病率，死亡率和医疗保健费用也在增加。它们是复杂且异质的病理，可能在不同主题中呈现出不同的病理方面，通常 随着个人发展。因此，需要鉴定具有相似特征，预后或治疗的患者，以定义所谓的表型，而且还需要标记每种表型内的特定差异，以定义内表型。 生物标志物对于研究呼吸表型和内型非常有用。代谢组学是最近引入的“组学”之一，正在成为生物标记物发现的领先技术。对于呼吸道，代谢组学似乎非常适合，因为呼吸道提供了一种天然基质，即呼出气冷凝物（EBC），可以在其中测量多种生物标志物。在这篇综述中，我们将讨论与核磁共振（NMR）谱和质谱（MS）在EBC代谢组学中研究呼吸系统疾病有关的主要方法学问题。

关键词: 气道疾病，呼出气冷凝物，肺，康复，质谱，代谢组学，NMR光谱。

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