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Review Article

克氏锥虫的巯基多胺代谢：分子靶标和药物再利用策略

卷 26, 期 36, 2019

页: [6614 - 6635] 页: 22

弟呕挨: 10.2174/0929867325666180926151059

价格: $65

摘要

在许多美国国家，恰加斯病仍然是一个充满挑战且被忽视的公共卫生问题。病原体克氏锥虫在哺乳动物宿主内细胞内发育，这阻碍了治疗功效。新型，安全和有效的治疗选择的发展并没有使寄生虫生物学和宿主-病原体相互作用的知识取得进步。因此，迫切需要寻找新颖的治疗药物并实施可能加快发现过程的药物发现策略。药物干预最吸引人的目标是病原体必需的目标，并在可能的情况下与宿主同源物不存在或有显着差异。 T. cruzi的硫醇-多胺代谢为合理设计选择性药物提供了有趣的候选对象。在这方面，在这里我们批判性地回顾了克氏锥虫硫醇多胺代谢的最新技术及其组分的药理潜力。另一方面，重新利用药物已成为一种有效的策略，可用于确定临床使用的药物的新生物活性，同时显着缩短了从头发现药物的时间和成本。因此，我们还讨论了可利用的不同药物重用策略，并特别强调了它们在鉴定针对克鲁氏梭菌硫醇-多胺代谢必需成分的候选药物中的应用。

关键词: 治疗，锥虫硫磷，亚精胺，多胺，恰加斯病，生物信息学，筛查，批准的药物，药物重新定位，药物重新利用。

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