摘要
环境对微生物产生强烈影响。 微生物适应不断变化的条件是由复杂网络调节的动态过程。 铜绿假单胞菌是一种生命威胁，多功能的机会性和多重耐药性病原体，为研究环境变化的适应机制提供了一种模型。 铜绿假单胞菌形成生物膜和改变环境变化毒力的能力由各种机制协调，包括双组分系统（TCS）和参与群体感应（QS）和c-di-GMP网络的二级信使（ 二鸟苷酸环化酶系统，DGC）。 在这篇综述中，我们关注c-di-GMP在生物膜形成过程中的作用。 我们描述了由c-di-GMP调节的TCS和QS信号级联响应外部环境的变化。 我们提出了一个复杂的信号网络，在铜绿假单胞菌从自由生长到无柄生长模式的转变过程中动态变化。
关键词: 铜绿假单胞菌，生物膜，双组分系统，二鸟苷酸环化酶系统，群体感应信号通路，生物标志物。
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