Targeting Nodal and Cripto-1: Perspectives Inside Dual Potential Theranostic Cancer Biomarkers

doi:10.2174/0929867325666180912104707
摘要

背景：阐明肿瘤发生过程中胚胎信号通路复发的机制已经导致发现了在正常发育过程中具有生理作用但在肿瘤中异常重新激活的癌 - 胎儿运动员。在这种情况下，Nodal和Cripto-1被认为是肿瘤发育因子，它们在正常组织中不存在但在几种实体肿瘤中过表达，在那里它们可以作为治疗诊断剂。目的：收集，回顾和讨论与Nodal和Cripto-1参与过度表达的几种肿瘤的发展，进展，复发和转移相关的最相关的论文，特别注意它们在癌干细胞（CSC）的相应亚群的表面。结果：我们收集，合理化并讨论了从大约370篇论文中提取的最有趣的发现，这些论文涉及Cripto-1和Nodal参与所有肿瘤类型的检测。数据证明了Nodal和Cripto-1存在之间的明显联系以及它们在不同肿瘤中的多种致癌活性。我们还回顾并强调了靶向Nodal，Cripto-1及其在肿瘤细胞表面形成的复合物，尤其是CSC的复合物的潜力，作为一种创新方法，用阻断一种或多种机制的分子来检测和抑制肿瘤。他们规范。结论：总体而言，Nodal和Cripto-1代表了两种创新且有效的生物标志物，用于开发针对正常和CSC亚群的潜在治疗性抗肿瘤药物，并克服药理学耐药性和肿瘤复发。
关键词: Nodal，Cripto-1，生物标志物，肿瘤，CSC，治疗药物。
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DOI https://dx.doi.org/10.2174/0929867325666180912104707	Print ISSN 0929-8673
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当代药物化学

针对Nodal和Cripto-1：双潜能治疗癌症生物标志物的观点

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当代药物化学

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