摘要
饮食和肠道微生物在阿尔茨海默氏症等神经退行性疾病的病理生理学中的作用最近受到了广泛的研究。研究表明人类肠道微生物区系可能有助于调节多种神经化学和神经代谢途径,通过与中枢神经系统相互作用和相互联系的复杂系统。脑和肠fORM是双向通讯轴,反之亦然,它们通过内分泌和复杂免疫系统之间的双向通讯形成轴,涉及神经递质和激素。AB型总之,研究表明,失调和多样化较差的微生物区系可能会干扰神经营养因子的合成和分泌,例如脑源性神经营养因子(Gammaaminob)。苹果酸和N-甲基D-天冬氨酸受体,广泛与认知功能减退和痴呆相关。在此背景下,本文回顾了关于gutbr作用的文献。阿尔茨海默病的AIN轴。
关键词: 大脑,中枢神经系统,肠道,微生物,肠道微生物,老年痴呆症。
Current Alzheimer Research
Title:Crosstalk between Gut Microbiota and Central Nervous System: A Focus on Alzheimer's Disease
Volume: 15 Issue: 13
关键词: 大脑,中枢神经系统,肠道,微生物,肠道微生物,老年痴呆症。
摘要: The role of diet and gut microbiota in the pathophysiology of neurodegenerative diseases, such as Alzheimer's, has recently come under intense investigation. Studies suggest that human gut microbiota may contribute to the modulation of several neurochemical and neurometabolic pathways, through complex systems that interact and interconnect with the central nervous system. The brain and intestine form a bidirectional communication axis, or vice versa, they form an axis through bi-directional communication between endocrine and complex immune systems, involving neurotransmitters and hormones. Above all, studies suggest that dysbiotic and poorly diversified microbiota may interfere with the synthesis and secretion of neurotrophic factors, such as brain-derived neurotrophic factor, gammaaminobutyric acid and N-methyl D-Aspartate receptors, widely associated with cognitive decline and dementia. In this context, the present article provides a review of the literature on the role of the gutbrain axis in Alzheimer's disease.
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Crosstalk between Gut Microbiota and Central Nervous System: A Focus on Alzheimer's Disease, Current Alzheimer Research 2018; 15 (13) . https://dx.doi.org/10.2174/1567205015666180904155908
DOI https://dx.doi.org/10.2174/1567205015666180904155908 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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