摘要
糖尿病是现代最受关注的疾病之一。尽管在治疗管理方面取得了相当大的进展，但糖尿病的流行及其对死亡和残疾的影响仍然是一个主要的健康问题。糖尿病血管病是糖尿病患者死亡和发病的主要原因。其病理生理学包括氧化应激、晚期糖基化终产物和低度炎症状态.近年来，天然免疫系统通过Toll样受体(Toll样受体)的作用被认为是这一领域的新发现。TLRs是由外源或内源性配体高度保守的结构单元激活的模式识别受体。热休克蛋白(Hsp)，通常以其在应激条件下保护细胞的能力而闻名，当损伤细胞释放出与TLR 4结合并在MyD 88依赖的途径中触发促炎细胞因子释放时。这一途径已经在胰腺β细胞和骨骼肌中被研究过，但还没有在血管系统中被发现，值得研究。本文对TLR 4和HSP 70在糖尿病血管中的相互作用进行了综述和讨论。目前的文献和我们实验室的初步结果表明，高血糖相关的HSP 70通过TLR 4途径在糖尿病血管病变的病理生理过程中起着重要的作用，可能成为治疗干预的新靶点。
关键词: 高血糖，Toll样受体4，热休克蛋白70，促炎症细胞因子，内皮功能障碍，糖尿病血管病变。
图形摘要
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