摘要
磷酸二酯酶10A(PDE10A)是水解环-3‘，5’-腺苷单磷酸(CAMP)和环-3‘，5’-鸟苷酸(CGMP)等第二信使分子的双底物酶。通过这一过程，PDE10A控制着哺乳动物大脑和外周组织中的细胞内信号通路。药理、生化和解剖学资料表明，PDE10A介导的第二信使系统的紊乱可能导致中枢神经系统(CNS)功能的损害，包括认知缺陷以及行为、情感处理和运动障碍。本文综述了PDE10A的详细描述和选择性PDE10A抑制剂设计的最新进展。本文还总结了PDE10A抑制剂治疗中枢神经系统相关疾病(如精神分裂症、亨廷顿病和帕金森病)的临床前研究结果。
关键词: PDE10A抑制剂，第二信使系统，SAR研究，中枢神经系统紊乱，罂粟碱相关化合物，异喹啉。
图形摘要
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