Abstract
Background: The electrochemical behavior of minoxidil on gold (Au), Glassy Carbon (GCEs), and Carbon Paste Electrodes (CPEs) was investigated in an aqueous supporting electrolyte (phosphate buffer [pH 2.0-6.5], acetate buffer [pH 4.3], and Britton and Robinson buffer [pH 2.0-7.4]).
Methods: For cyclic voltammetric measurements with suitable methodical parameters, CPEs catalyze electrooxidation of minoxidil more efficiently than do other electrodes. Minoxidil was detected using high-performance liquid chromatography with an electrochemical (carbon paste) detector (HPLCECD). For direct current mode, with the current at a constant potential, and measurements with suitable experimental parameters, a linear concentration from 0.02 to 2.6 mg L-1 was found. The detection limit was approximately 20 ng m L-1.
Results: The developed method detected minoxidil samples.
Conclusion: Findings using HPLC-ECD and HPLC with an ultraviolet detector were comparable.
Keywords: Hair-growth pharmaceuticals, minoxidil, voltammetric sensor, gold (Au), glassy carbon (GCEs), carbon paste electrodes (CPEs).
Graphical Abstract
[1]
Choi, J.H.; Seo, J.A.; Park, W.S.; Shin, H.J.; Park, Y.H. Hair
growth stimulants containing tretinoin and minoxidil or derivatives
thereof. Repub. Korean Kongkae Taeho Kongbo,, 2015.KR
2015068800 A, 20150622..
[2]
Mitsui, Y.; Imada, K. Hair growth stimulant containing minoxidil
derivative and percutaneous absorption enhancer, hair care system,
and production thereof. Jpn. Kokai Tokkyo Koho, 2015.JP
2015101557 A, 20150604.
[3]
Cifter, U.; Tuerkyilmaz, A.; Yelken, G.; Zan, M. Hair care formulations
comprising minoxidil and a penetration enhancer. PCT Int.
Appl, 2014.WO 2014184173 A1, 20141120..
[4]
Rafi, A.; Katz, R.M. A composition comprising finasteride and
dutasteride and minoxidil for treating hair loss. U.S. Pat. Appl.
Publ, 2012.US 20120258972 A1, 20121011.
[5]
Mapar, M.A.; Omidian, M. Is topical minoxidil solution effective on androgenetic alopecia in routine daily practice? J. Dermatolog. Treat., 2007, 18(5), 268-270.
[6]
Kvedar, J.C.; Baden, H.P. Topical minoxidil in the treatment of male pattern alopecia. Pharmacotherapy, 1987, 7(6), 191-197.
[7]
Olsen, E.A.; DeLong, E.R.; Weiner, M.S. Dose-response study of topical minoxidil in male pattern baldness. J. Am. Acad. Dermatol., 1986, 15(1), 30-37.
[8]
Fiedler-Weiss, V.C.; Rumsfield, J.; Buys, C.M.; West, D.P.; Wendrow, A. Evaluation of oral minoxidil in the treatment of alopecia areata. Arch. Dermatol., 1987, 123(11), 1488-1490.
[9]
Vera, H.P. Double-blind placebo-controlled evaluation of topical minoxidil in extensive alopecia areata. J. Am. Acad. Dermatol., 1987, 16(3 Pt 2), 730-736.
[10]
Adelino de Sousa, R.; Semaan, F.S.; Cervini, P.; Cavalheiro, E.T. Determination of minoxidil by bleaching the permanganate carrier solution in a flow-based spectrophotometric system. Anal. Lett., 2011, 44(1-3), 349-359.
[11]
Bordbar, M.; Yeganeh-Faal, A.; Ghasemi, J.; Ahari-Mostafavi, M.M.; Sarlak, N.; Baharifard, M.T. Simultaneous spectrophotometric determination of minoxidil and tretinoin by the H-point standard addition method and partial least squares. Chem. Pap., 2009, 63(3), 336-344.
[12]
Adelino de Sousa, R.; Semaan, F.S.; Baio, J.A.; Cavalheiro, E.T. Fast determination of minoxidil by photometric flow titration. Eclét. Quím., 2005, 30(3), 79-84.
[13]
Ruiz-Medina, A.; Fernandez-de, C.M.; Molina-Diaz, A. Integrated flow injection-solid phase spectrophotometric determination of minoxidil. Talanta, 1999, 50(2), 277-282.
[14]
Wu, C.S.; Jin, Y.; Zhang, J.L.; Ren, Y.; Jia, Z.X. Simultaneous determination of seven prohibited substances in cosmetic products by liquid chromatography-tandem mass spectrometry. Chin. Chem. Lett., 2013, 24(6), 509-511.
[15]
De Orsi, D.; Pellegrini, M.; Pichini, S.; Mattioli, D.; Marchei, E.; Gagliardi, L. High-performance liquid chromatography-diode array and electrospray-mass spectrometry analysis of non-allowed substances in cosmetic products for preventing hair loss and other hormone-dependent skin diseases. J. Pharm. Biomed. Anal., 2008, 48(3), 641-648.
[16]
Gong, Y.Q.; Lu, G.X. Determination of illegally added minoxidil in herbal hair growth cosmetics by HPLC. Shipin Yu Yaopin, 2014, 16(4), 267-269.
[17]
Xiong, X.T.; Tan, J.H.; Li, H.Y.; Zhao, T.T.; Zhao, Q.W.; Jia, F.; Wang, J.C.; Xi, S.F.; Wu, Y.L. Rapid determination of 8 prohibited drugs in hair growth cosmetics by HPLC/DAD. Fenxi Ceshi Xuebao, 2013, 32(4), 448-453.
[18]
Huang, T.; Garceau, M.E.; Ramstad, T.; Stehle, R.G. Rapid determination of trace amounts of minoxidil in hamster skin follicles with various formulations using narrow-bore LC/EC. J. Pharm. Biomed. Anal., 2005, 38(3), 532-536.
[19]
Golden, M.H.; Zoutendam, P.H. The determination of minoxidil in human serum by high-performance liquid chromatography with amperometric detection. J. Pharm. Biomed. Anal., 1987, 5(6), 543-551.
[20]
Carrum, G.; Abernethy, D.R.; Sadhukhan, M.; Wright, C.E. Minoxidil analysis in human plasma using high-performance liquid chromatography with electrochemical detection. Application to pharmacokinetic studies. J. Chromatogr. A, 1986, 381(1), 127-135.
[21]
Pfaffen, V.; Ortiz, P.I. Electrochemical determination of minoxidil in different pharmaceutical formulations by flow injection analysis. Anal. Sci., 2006, 22(1), 91-94.
[22]
Gibson, G.; Ramstad, T.; Mills, K.A.; Dunn, M.J. A method for the determination of minoxidil in hair-regrowth formulations by micellar electrokinetic capillary chromatography. Farmaco, 2005, 60(10), 847-853.
[23]
Patterson, S.C.; Ramstad, T.; Mills, K.A. Development and validation of a procedure for the determination of minoxidil in hair-regrowth formulations using 2 variants of capillary zone electrophoresis. Farmaco, 2005, 60(6-7), 547-554.
[24]
Adelino de Sousa, R.; Cavalheiro, E.T. Potentiometric determination of minoxidil in topical use pharmaceutical samples. Eclét. Quím., 2009, 34(2), 23-27.
[25]
Karimian, N.; Gholivand, M.B.; Taherkhani, F. Computational design and development of a novel voltammetric sensor for minoxidil detection based on electropolymerized molecularly imprinted polymer. J. Electroanal. Chem. , 2015, 740, 45-52.
[26]
Sousa, R.A.; Dos-Santos, S.X.; Cavalheiro, E.T.; Brett, C.M. Graphite-polyurethane and graphite-silicone rubber composite electrodes for electrochemical characterization and determination of minoxidil. Electroanalysis, 2013, 25(3), 706-715.
[27]
Ahmadi, F.; Ghasemi, S.; Rahimi-Nasrabadi, M. Adsorptive cathodic stripping determination of minoxidil in pharmaceutical, cream and shampoo products. Collect. Czech. Chem. Commun., 2011, 76(5), 371-382.
[28]
Amankwa, L.; Chatten, L.G.; Pons, S. Electrochemical studies on minoxidil and its determination in tablets by differential-pulse polarography. Analyst (Cambridge, UK), 1983, 108(1291), 1221-1226.
[29]
Wang, L.H. Simultaneous determination of hydroquinone ethers in cosmetics after preconcentration at a carbon paste electrode. Analyst , 1995, 120(8), 2241-2244.
[30]
Wang, L.H.; Chen, Z.S. Determination of thioglycolic acid and cysteine in hair-treatment products at ceramic carbon composite electrodes. Electroanalysis, 1997, 9(15), 312-317.
[31]
Wang, L.H.; Chen, Z.S. Determination of phenylenediamines in oxidative hair dyes by differential pulse voltammetry. J. Chin. Chem. Soc. , 1998, 45(1), 53-58.
[32]
Wang, L.H. Determination of zinc pyrithione in hair-care products on metal oxides modified carbon electrodes. Electroanalysis, 2000, 12(3), 227-232.
[33]
Wang, L.H.; Tseng, S.W. Determination of D-panthenol and salt of pantothenic acid in cosmetic and pharmaceutical preparations by differential pulse voltammetry. Anal. Chim. Acta, 2001, 432, 39-48.
[34]
Wang, L.H.; Tien, H.J.; Tai, C. Use of disposable modified carbon paste electrode for liquid chromatography-amperometric detection of theophylline and three of metabolites in human serum. J. Chin. Chem. Soc. , 2006, 53, 1523-1530.
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