Carbohydrates: Potential Sweet Tools Against Cancer

doi:10.2174/0929867325666180719114150
摘要

癌症是当今最破坏性的退化性疾病之一，是药物化学和制药行业的主要目标之一。由于世界人口中癌症发病率的显着增加，以及这种疾病的复杂性（具有多因素性质），迫切需要针对与癌症有关的不同生物学靶标的新药物。在具有抗肿瘤活性的大量化合物中，该综述将涵盖碳水化合物衍生物作为特有支架的用途。它们的亲水性，以及与细胞表面的生物受体建立选择性相互作用的能力，参与细胞间的通讯过程，已经开发出了许多可用于癌症治疗的新模板。它们固有的水溶性使其可以用作前药载体，以更有效地获得药物靶标。其中将碳水化合物束缚到药效基团的糖缀合物的制备还允许药物更好地透过细胞膜渗透，其中涉及与碳水化合物基序的选择性相互作用。在这种情况下，已经证明了多价结构（例如金纳米颗粒）的设计增强了与生物受体如凝集素，糖蛋白的关键相互作用，所述生物受体可能与癌症的进展有关。此外，通过掺入金属络合物或通过用杂原子代替其内环氧或碳原子来修饰碳水化合物的结构基序，导致了新的抗肿瘤剂。这种具有相关抗肿瘤活性的糖基模板的多样性将在本综述中介绍。
关键词: 癌症，碳水化合物，糖结合物，药物载体，金属络合物，多价，癌症疫苗。
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DOI https://dx.doi.org/10.2174/0929867325666180719114150	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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