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Review Article

C-肉桂酰糖苷：选择性碳酸酐酶抑制剂发展的新兴“尾巴”

卷 26, 期 15, 2019

页: [2601 - 2608] 页: 8

弟呕挨: 10.2174/0929867325666180713122907

价格: $65

摘要

不同尾部与众所周知的碳酸酐酶（CA）药效团的连接导致了几种新的CA抑制剂（CAI）的开发。 这种“尾巴”的一个非常好的例子是碳水化合物，它代表了广泛的化学型，从而导致大量新的CAI。 在过去几年中，已经制备了几种含有不同支架的C-肉桂酰基糖苷并作为碳酸酐酶抑制剂进行了研究，表明它们中的一些是非常有效和选择性的CAI。 本文将回顾这些Cglycosides的合成和生物活性的最新发展。

关键词: 碳水化合物，酶抑制，抗肿瘤，结核，杂环，CAI，碳酸酐酶。

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