摘要
阿尔茨海默病(AD)和血管性痴呆(VAD)等2型糖尿病(DM)增加了认知能力下降和痴呆的风险。除了AD和VAD, 可能有一个痴呆亚组与特定的DM相关代谢异常有关,而不是AD病理或脑血管病,称为糖尿病相关痴呆(DRD)。 方法:对31例DRD患者和5例AD伴DM患者的11C-PIB和11C-PBB3正电子发射断层扫描(PET)进行了研究。 结果:所有AD患者PIB和PBB 3均为阳性。然而,31例DRD患者中只有12例(39%)PIB阳性,而在21例接受PBB 3 PET检查的患者中,17例(81%)显示PIB阳性。 ED阳性PBB 3。根据PIB和PBB 3的阳性率,我们将21例患者分为PIB阴性组和PBB 3阳性组(11例,52%),提示PIB阳性,pos阳性。 提示AD病理的PBB 3型6例(29%),PIB阴性4例(19%),PBB 3型阴性4例(19%)。在11名PIB阴性和PBB 3阳性的受试者中,我们 Re_2PBB_3沉积模式,包括内侧颞叶和内侧颞叶以外广泛的新皮质。 结论:DRD在脑组织中表现出不同的淀粉样蛋白和τ积聚模式。除AD病理和非淀粉样蛋白/非τ神经元外,DRD可能主要与τ病理有关。 糖尿病相关代谢异常造成的损害。
关键词: 动物相关痴呆,正电子发射断层扫描,淀粉样蛋白,τ,11C-PIB,11C-PBB3。
Current Alzheimer Research
Title:Amyloid and Tau Positron Emission Tomography in Suggested Diabetesrelated Dementia
Volume: 15 Issue: 11
关键词: 动物相关痴呆,正电子发射断层扫描,淀粉样蛋白,τ,11C-PIB,11C-PBB3。
摘要: Background: Type 2 diabetes mellitus (DM) has been shown to increase the risk for cognitive decline and dementia, such as Alzheimer disease (AD) and vascular dementia (VaD). In addition to AD and VaD, there may be a dementia subgroup associated with specific DM-related metabolic abnormalities rather than AD pathology or cerebrovascular disease, referred to as diabetes-related dementia (DrD).
Method: We studied 11C-PiB and 11C-PBB3 positron emission tomography (PET) in 31 subjects with DrD and 5 subjects with AD associated with DM to assess amyloid and tau deposits in the brain.
Results: All subjects with AD showed both positive PiB and PBB3. However, only 12 out of 31 subjects (39%) with DrD showed positive PiB, whereas 17 out of 21 subjects (81%) who underwent PBB3 PET showed positive PBB3. Depending on the positivity of PiB and PBB3, we classified 21 subjects into a negative PiB and a positive PBB3 pattern (11 cases, 52%), indicating tauopathy, a positive PiB and a positive PBB3 pattern (6 cases, 29%), indicating AD pathology, or a negative PiB and a negative PBB3 pattern (4 cases, 19%). Among 11 subjects showing a negative PiB and a positive PBB3 pattern, there were 2 PBB3 deposit patterns, including the medial temporal lobe only and extensive neocortex beyond the medial temporal lobe.
Conclusion: DrD showed variable amyloid and tau accumulation patterns in the brain. DrD may be associated predominantly with tau pathology, in addition to AD pathology and non-amyloid/non-tau neuronal damage due to DM-related metabolic abnormalities.
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Amyloid and Tau Positron Emission Tomography in Suggested Diabetesrelated Dementia, Current Alzheimer Research 2018; 15 (11) . https://dx.doi.org/10.2174/1567205015666180709113338
DOI https://dx.doi.org/10.2174/1567205015666180709113338 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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