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Review Article

黄酮类化合物生物活性的机制

卷 26, 期 39, 2019

页: [6976 - 6990] 页: 15

弟呕挨: 10.2174/0929867325666180706104829

价格: $65

摘要

黄酮类化合物是在人类饮食中广泛分布的酚类化合物。它们的摄入与减少各种疾病（如癌症，免疫功能障碍或冠心病）的风险有关。然而，关于其体内活性背后的机制的知识是有限的，并且仍在讨论中。多年来，它们的生物活性与酚类化合物的直接抗氧化剂和自由基清除性能有关，但如今，这种假设不太可能解释其假定的健康影响，或者至少是对其唯一的解释。已经提出了有关可能机制的新假设，包括多酚与肠道菌群相互作用的影响，以及类黄酮或其代谢产物可能修饰基因表达或充当细胞内信号级联反应的潜在调节剂的可能性。本文回顾了所有这些主题，从在氧化应激理论的背景下作为抗氧化剂的经典观点，到与氧化还原信号通路的调节，基因表达的修饰或与肠道菌群相互作用有关的最新趋势。还讨论了将秀丽隐杆线虫作为模型生物用于研究类黄酮生物活性的分子机制。

关键词: 类黄酮，对健康的影响，生物利用度，代谢物，肠道菌群，抗氧化剂，基因表达，秀丽隐杆线虫。

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