Abstract
Background: Polymer nanogels are increasingly used for the encapsulation of nano-solids and quantum dots such as in advanced forms of drug and therapeutic isotope delivery.
Objective: Unlike ex vivo application of systems in vivo application and internalization are likely to suffer from aspects of failure to ensure safety and biocompatibility. Biocompatible hydrophilic poloxamer (Pluronic F108 and F68) micelles were studied by light scattering and tensiometry.
Methods: The micelles of nano-gels are synthetic heteropolymer aggregates, which are used to encapsulate drugs but in this study chemically-modified (hydrophobized) copper nano-spheres, for the purposes of demonstration for further application and medical use. Copper benzoate nano-particles (CuBzNPs) were produced by maceration and subsequently stabilized in Pluronic F108 solution was added at different concentrations.
Results: The resulting particle size increase was studied by dynamic light scattering. Moderate size increase was observed at low Pluronic F108 concentrations, which indicated successful coating, but at higher F108 concentrations large size agglomerates formed. Coated copper benzoate nano-particles (CuBzNPs) were fabricated as a proof-of-principle and as a substitute for bare metal nano-particles (MNs), which were not successfully entrained in the poloxamer nano-gel. As part of the synthesis copper benzoate (CuBz) beads and their characterization through contact angle measurements were performed.
Conclusion: Micelles sizes of 4 nm for F68 Pluronic at equilibrium surface tensions of 36 mNm-1 were captured in weak, 1.25 to 2.0 Pas pseudoplastic gels fabricated from hydroxypropylmethylcellulose (HPMC).
Keywords: Encapsulation, hydrophobic, nano-gel, nano-solids, micelle, therapy.
Graphical Abstract
[1]
Juzenas P, Chen W, Sun Y-P, et al. Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer. Adv Drug Deliv Rev 2008; 60(15): 1600-14.
[2]
Janib SM, Moses AS, MacKay JA. Imaging and drug delivery using theranostic nanoparticles. Adv Drug Deliv Rev 2010; 62(11): 1052-63.
[3]
El-Trass A, ElShamy H, El-Mehasseb I, et al. CuO nanoparticles: Synthesis, characterization, optical properties and interaction with amino acids. Appl Surf Sci 2012; 258: 2997-3001.
[4]
Gopal A, Kant V, Gopalakrishnan A, et al. Chitosan-based copper nanocomposite accelerates healing in excision wound model in rats. Eur J Pharmacol 2014; 731: 8-19.
[5]
Rezaeifard A, Jafarpour M, Naeimi A, et al. Highly selective aqueous heterogeneous oxygenation of hydrocarbons catalyzed by recyclable hydrophobic copper (II) phthalocyanine nanoparticles. J Mol Catalysis A: Chem 2012; 357: 141-7.
[6]
Bahadar H, Maqbool F, Niaz K, et al. Toxicity of nanoparticles and an overview of current experimental models. Iran Biomed J 2016; 20(1): 1-11.
[7]
Bondarenko O, Juganson K, Ivask A, et al. Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: A critical review. Arch Toxicol 2013; 87: 1181-200.
[9]
Tsapis N, Bennett D, Jackson B, et al. Trojan particles: Large porous carriers of nanoparticles for drug delivery. Proc Natl Acad Sci USA 2002; 99(19): 12001-5.
[10]
David Gara PM, Garabano N, Llansola Portoles MJ, et al. ROS enhancement by silicon nanoparticles in X-ray irradiated aqueous suspensions and in glioma C6 cells. J Nanopart Res 2012; 14(3): 1-13.
[11]
Li W-R, Xie X-B, Shi Q-S, et al. Antibacterial activity and mechanism of silver nanoparticles on Escherichia coli. Appl Microbiol Biotechnol 2010; 85(4): 1115-22.
[12]
Dichello GA, Sarker DK. In: Grumezescu A, Ficai A, Eds. Nanostructures in therapeutic medicine, volume 2: Nanostructures for antimicrobial therapy. Netherlands: Elsevier 2016: pp. 272-313.
[13]
Jain PK, Huang X, El-Sayed IH, et al. Noble metals on the nanoscale: Optical and photothermal properties and some applications in imaging, sensing, biology, and medicine. Acc Chem Res 2008; 41(12): 1578-86.
[14]
Takahashi M, Mohan P, Nakade A, et al. Ag/ FeCo/ Ag Core/Shell/Shell magnetic nanoparticles with plasmonic imaging capability. Langmuir 2015; 31(7): 2228-36.
[15]
Gaucher G, Dufresne M-H, Sant VP, et al. Block copolymer micelles: Preparation, characterization and application in drug delivery. J Control Release 2005; 109(1-3): 169-88.
[16]
Kozlov MY, Melik-Nubarov NS, Batrakova EV, et al. Relationship between pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes. Macromol 2000; 33(9): 3305-13.
[17]
Lo C-L, Lin S-J, Tsai H-C, et al. Mixed micelle systems formed from critical micelle concentration and temperature-sensitive diblock copolymers for doxorubicin delivery. Biomat 2009; 30(23-24): 3961-70.
[18]
Mistry K, Sarker DK. SLNs can serve as the new brachytherapy seed: determining influence of surfactants on particle size of solid lipid microparticles and development of hydrophobised copper nanoparticles for potential insertion. J Chem Eng Proc Technol 2016; 7(3): 1-9.
[19]
Dichello GA, Fukuda T, Maekawa T, et al. Preparation of liposomes containing small gold nanoparticles using electrostatic interactions. Eur J Pharm Sci 2017; 105: 55-63.
[20]
Kim TJ, Chae KS, Chang Y, et al. Gadolinium oxide nanoparticles as potential multi-modal imaging and therapeutic agents. Curr Top Med Chem 2013; 13(4): 422-33.
[21]
Mody VV, Siwale R, Singh A, et al. Introduction to metallic nanoparticles. J Pharm Bioallied Sci 2013; 2(4): 282-9.
[22]
Baek Y-W, An Y-J. Microbial toxicity of metal oxide nanoparticles (CuO, NiO, ZnO and Sb2O3) to Escherichia coli, Bacillus subtilis and Staphylococcus aureus. Sci Total Environ 2011; 409(8): 1063-8.
[23]
Zhang Q, Zhang K, Xu D, et al. CuO Nanostructures: Synthesis, characterization, growth mechanisms, fundamental properties and applications. Prog Mater Sci 2014; 60: 208-337.
[24]
Avgoustakis K, Beletsi A, Panagi Z, et al. PLGA-mPEG nanoparticles of cisplatin: in vitro nanoparticle degradation and in vivo residence in blood properties. J Control Release 2002; 79: 123-35.
[25]
Gamucci O, Bertero A, Gagliardi M, et al. Biomedical nanoparticles: Overview of their surface immune-compatibility. Coatings 2014; 4(1): 139-59.
[26]
Sabella S, Carney RP, Brunetti V, et al. A general mechanism for intracellular toxicity of metal-containing nanoparticles. Nanoscale 2014; 6(12): 7052-61.
[27]
Chang H, Chen X-Q, Jwo C-S, et al. Electrostatic and sterical stabilization of cuo nanofluid prepared by vacuum arc spray nanofluid synthesis system (ASNSS). Mater Trans 2009; 50(8): 2098-103.
[28]
Aruoja V, Dubourgier H-C, Kasemets K, et al. Toxicity of nanoparticles of CuO, ZnO and TiO2 to microalgae Pseudokirchneriella subcapitata. Sci Total Environ 2009; 407(4): 1461-8.
[29]
Onoshima D, Yukawa H, Baba Y. Multifunctional quantum dots-based cancer diagnostics and stem cell therapeutics for regenerative medicine. Adv Drug Deliv Rev 2015; 95(1): 2-14.
[30]
Kharlamov AN, Tyurnina AE, Veselova VS, et al. Silica-gold nanoparticles for atheroprotective management of plaques: Results of the NANOM-FIM trial. Nanoscale 2015; 7(17): 8003-15.
[31]
Lajunen T, Viitala L, Kontturi L-S, et al. Light induced cytosolic drug delivery from liposomes with gold nanoparticles. J Control Release 2015; 203: 85-98.
[32]
Thanh NTK, Green LAW. Functionalisation of nanoparticles for biomedical applications. Nano Today 2010; 5(3): 213-30.
[33]
Locatelli E, Broggi F, Ponti J, et al. Lipophilic silver nanoparticles and their polymeric entrapment into Targeted-PEG-Based micelles for the treatment of glioblastoma. Adv Healthc Mater 2012; 1(3): 342-7.
[34]
Sarker DK. In: Tiwari A, Ramalingam M, Kobayashi h, Turner APF, Eds. Biomedical materials and diagnostic devices, Chapter 13, Part III. New York: Scrivener Publishing 2012: pp. 395-434.
[35]
Sarker DK. Architectures and mechanical properties of drugs and complexes of surface-active compounds at air-water and oil-water interfaces. Curr Drug Discov Technol 2018; 14: 1-24.
[36]
Ponnappan N, Chugh A. Nanoparticle-Mediated delivery of therapeutic drugs. Pharmaceut Med 2015; 29(3): 155-67.
[37]
Howell M, Mallela J, Wang C, et al. Manganese-loaded lipid-micellar theranostics for simultaneous drug and gene delivery to lungs. J Control Release 2013; 167(2): 210-8.
[38]
Probst CE, Zrazhevskiy P, Bagalkot V, et al. Quantum dots as a platform for nanoparticle drug delivery vehicle design. Adv Drug Deliv Rev 2013; 65(5): 703-18.
[39]
Collins G, Patel A, Dilley A, et al. Molecular modeling directed by an interfacial test apparatus for the evaluation of protein and polymer ingredient function in situ. J Agric Food Chem 2008; 56(10): 3846-55.
[40]
Al-Hanbali O, Rutt KJ, Sarker DK, et al. Concentration dependent structural ordering of Poloxamine 908 on polystyrene nanoparticles and their modulatory role on complement consumption. J Nanosci Nanotechnol 2006; 6(9): 3126-33.
[41]
Georgiev GA, Sarker DK, Al-Hanbali O, et al. Effects of poly(ethylene glycol) chains conformational transition on the properties of DMPC/DMPE-PEG thin liquid films and monolayers. Colloids Surf B Biointerfaces 2007; 59(2): 184-93.
[42]
Umlong IM, Ismail K. Micellization behavior of sodium dodecyl sulfate in different electrolyte media. Colloids Surf A Physicochem Eng Asp 2007; 299(1): 8-14.
[43]
Corrin ML, Harkins WD. The Effect of salts on the critical concentration for the formation of micelles in colloidal electrolytes. J Am Chem Soc 1947; 69(3): 683-8.
[44]
Alexandridis P, Hatton TA. Poly(ethylene oxide)-poly(propylene oxide)-poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling. Colloids Surf A Physicochem Eng Asp 1995; 96: 1-46.
[45]
Alexandridis P, Holzwarth JF, Hatton TA. Micellization of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) triblock copolymers in aqueous solutions: Thermodynamics of copolymer association. Macromol 1994; 27(9): 2414-25.
[46]
Sharma PK, Reilly MJ, Jones DN, et al. The effect of pharmaceuticals on the nanoscale structure of PEO-PPO-PEO micelles. Colloids Surf B Biointerfaces 2008; 61(1): 53-60.
[47]
Mout R, Moyano DF, Rana S, et al. Surface functionalization of nanoparticles for nanomedicine. Chem Soc Rev 2012; 41(7): 2539-44.
[48]
Beatty SM, Smith JE. Fractional wettability and contact angle dynamics in burned water repellent soils. J Hydrol 2010; 391(1-2): 97-108.
[49]
Marmur A. Soft contact: measurement and interpretation of contact angles. Soft Matter 2006; 2(1): 12-7.
[50]
Bayer IS, Fragouli D, Martorana PJ, et al. Solvent resistant superhydrophobic films from self-emulsifying carnauba wax-alcohol emulsions. Soft Matter 2011; 7: 7939.
[51]
Mańko D, Zdziennicka A, Jańczuk B. Surface tension of polytetrafluoroethylene and its wetting by aqueous solutions of some surfactants and their mixtures. Appl Surf Sci 2017; 392: 117-25.
[52]
Andrieu C, Sykes C, Brochard F. Average spreading parameter on heterogeneous surfaces. Langmuir 1994; 10(7): 2077-80.
[53]
Decker EL, Frank B, Suo Y, et al. Physics of contact angle measurement. Colloids Surf A Physicochem Eng Asp 1999; 156(1-3): 177-89.
[54]
Deguchi S, Mukai S-A, Tsudome M, et al. Facile generation of fullerene nanoparticles by hand-grinding. Adv Mater 2006; 18(6): 729-32.
[55]
Striemer CC, Fauchet PM, McGrath JL, et al. Charge- and size-based separation of macromolecules using ultrathin silicon membranes. Nature 2007; 445(7129): 749-53.
[56]
Dutta A, Dolui SK. Preparation of colloidal dispersion of CuS nanoparticles stabilized by SDS. Mater Chem Phys 2008; 112(2): 448-52.
[57]
Almgren M, Gimel JC, Wang K, et al. SDS micelles at high ionic strength. a light scattering, neutron scattering, fluorescence quenching, and CryoTEM investigation. J Colloid Interface Sci 1998; 202(2): 222-31.
[58]
Allen C, Maysinger D, Eisenberg A. Nano-engineering block copolymer aggregates for drug delivery. Colloids Surf B Biointerfaces 1999; 16(1-4): 3-27.
[59]
Alexandridis P, Nivaggioli T, Hatton TA. Temperature effects on structural properties of Pluronic P104 and F108 PEO-PPO-PEO block copolymer solutions. Langmuir 1995; 11(5): 1468-76.
[60]
Santander-Ortega MJ, Jódar-Reyes AB, Csaba N, et al. Colloidal stability of Pluronic F68-coated PLGA nanoparticles: A variety of stabilization mechanisms. J Colloid Interface Sci 2006; 302(2): 522-9.
[61]
Trokhymchuk A, Henderson D. Depletion forces in bulk and in confined domains: From Asakura-Oosawa to recent statistical physics advances. Curr Opin Colloid Interface Sci 2015; 20(1): 32-8.
[62]
Tiraferri A, Chen KL, Sethi R, and Elimelech M. Reduced aggregation and sedimentation of zero-valent iron nanoparticles in the presence of guar gum. J Colloid Interface Sci 2008; 324(1-2): 71-9.
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