Abstract
Background: Some of chemical syntheses are attractive because of their pharmacological application in the drug industry.
Materials and Methods: In this study, water soluble peripherally and non-peripherally tetra substituted novel zinc (II) phthalocyanines, which were tagged as ZnPC, investigated against the inhibition of urease and hyaluronidase (HYA). In addition to enzyme inhibitory activities, antioxidant activity of synthesis molecules was measured by Ferric Reducing Antioxidant Power (FRAP) and DPPH radical scavenging activity assays.
Results: The study also showed that four synthesis extracts exhibited a potent hyaluronidase and urease inhibitory effects with IC50 value ranges 7.095-115.878 µM and 4.227-35.678 µM respectively. Besides ZnPC-1 exhibited efficient urease and HYA inhibition, it showed good antioxidant activity with 0.341±0.001 µmol FeSO4.7H2O/mg sample for FRAP and 16.917±0.005 µM for DPPH. Also, the results obtained in the present study indicate that zinc (II) phthalocyanines compounds can be a potential source of bioactive agents.
Keywords: DPPH, FRAP, hyaluronidase, phthalocyanines, urease, zinc.
Graphical Abstract
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