摘要
背景:扩散张量成像法测定海马平均扩散系数(MD)是诊断轻度认知损害(MCI)和痴呆的一种很有前途的指标。它的性能还有待评估。 适用于初级保健病人,他们系统地不同,从病人到专门护理机构访问。 目的:评价海马扩散率对初诊人群MCI和痴呆的诊断准确性,并与专科护理样本进行比较。 方法:从初诊干预试验(Delphi-MV)(70例)中抽取一例,从我们的记忆诊所收集另一例(70例)。样品成对配对,用于诊断。 认知,MMSE,年龄,性别和教育程度。他们包括痴呆患者,MCI患者和健康者。计算左、右海马平均MD值,校正部分体积效应。 恩斯。在每个样本中,左、右海马MD作为Logistic回归诊断组的预测指标,再加控制白质病变。 结果:在初级保健样本中,海马MD检测到的痴呆具有较高的交叉验证准确率(左:aUC=.92;右:aUC=.85),但没有准确地对MCI进行高于概率的分类(左: AUC=.58;右:AUC=.44)。在记忆临床样本中,海马MD分为痴呆组(左侧:AUC=.91;右侧:AUC=.91)和MCI组(左:AUC=.86;右侧:AUC=.83)。 yard 码 结论:海马MD支持痴呆的鉴别,但对初级保健人群MCI的检测无帮助。
关键词: 扩散张量成像,平均扩散率,海马,初级保健,痴呆,诊断,阿尔茨海默病。
Current Alzheimer Research
Title:Hippocampal Mean Diffusivity for the Diagnosis of Dementia and Mild Cognitive Impairment in Primary Care
Volume: 15 Issue: 11
关键词: 扩散张量成像,平均扩散率,海马,初级保健,痴呆,诊断,阿尔茨海默病。
摘要: Background: Hippocampal mean diffusivity (MD) measured by Diffusion-Tensor Imaging is a promising diagnostic marker for Mild Cognitive Impairment (MCI) and dementia. Its performance has yet to be evaluated in primary care patients, who vary systematically from patients visiting specialized care settings.
Objective: We assessed the diagnostic accuracy of hippocampus diffusivity for detecting MCI and dementia in a sample recruited from primary care, compared to a sample from specialized care.
Method: One sample was recruited from a primary care intervention trial (DelpHi-MV) (n=70), and the other sample was recruited from our memory clinic (n=70). The samples were matched pairwise for diagnosis, MMSE, age, gender, and education. They included dementia patients, MCI patients and healthy subjects. Mean MD was calculated for the left and right hippocampus, corrected for partial volume effects. Within each sample, left or right hippocampal MD served as predictor for diagnostic group in logistic regressions, which were additionally controlled for white matter lesions.
Results: In the primary care sample, hippocampal MD detected dementia with high cross-validated accuracy (left: AUC=.92; right: AUC=.85), but did not classify MCI with an accuracy above chance (left: AUC=.58; right: AUC=.44). In the memory clinic sample, hippocampal MD classified both dementia (left: AUC=.91; right: AUC=.91) and MCI (left: AUC=.86; right: AUC=.83) with high cross-validated accuracy.
Conclusion: Hippocampal MD supported the identification of dementia but did not contribute to the detection of MCI in the primary care patient population.
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Hippocampal Mean Diffusivity for the Diagnosis of Dementia and Mild Cognitive Impairment in Primary Care, Current Alzheimer Research 2018; 15 (11) . https://dx.doi.org/10.2174/1567205015666180613114829
DOI https://dx.doi.org/10.2174/1567205015666180613114829 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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