Dual Inhibitors as a New Challenge for Cancer Multidrug Resistance Treatment

doi:10.2174/0929867325666180607094856
摘要

背景：单一药物在癌症治疗中的双重靶向是与药物组合相关的非常规方法。开发双重靶向剂的基本原理是克服使用个别靶向剂时经常出现的不完全功效和耐药性。因此，通过双重靶向策略有望获得更理想的癌症治疗结果。方法：我们回顾了文献，着重于临床相关和/或新型双重抑制剂之间的关联，这些抑制剂具有调节癌细胞多药耐药表型，特别是P-糖蛋白活性的潜力。对内容进行了平衡分析，以强调最重要的发现并优化本评价的结构。结果：245篇论文被纳入评价。引言部分由9篇论文解释。 87篇论文阐明了酪氨酸激酶抑制剂在抑制糖蛋白和化学增敏中的作用。使用92篇论文综述了天然化合物在克服多药耐药性方面的贡献，而55篇论文描述了针对微管组装和/或拓扑异构酶的特定双重抑制剂。有11篇论文对杂种药物的一种新颖且鲜为人知的方法进行了深入分析。还评估了它们对P-糖蛋白和多药耐药性的影响。结论：这些发现使重点关注双靶点药物的合理抗癌策略。评估最多的合成药物和天然药物在化学增敏方面显示出巨大潜力。为了优化抗癌治疗，需要朝这个方向采取进一步的措施。
关键词: 靶向抗癌治疗，多药耐药性，P-糖蛋白，酪氨酸激酶抑制剂，天然药物，微管相互作用剂，拓扑异构酶抑制剂，杂合化合物
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DOI https://dx.doi.org/10.2174/0929867325666180607094856	Print ISSN 0929-8673
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当代药物化学

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