摘要
念珠菌是导致感染（念珠菌病）的主要人类真菌病原体，主要在老年人和免疫功能低下的宿主中。即使念珠菌属。是共生中口腔微生物群的成员，在某些情况下，它会导致微生物失衡导致生态失调，导致口腔疾病。由于几种抗真菌药物的活性受到损害，因此迫切需要替代疗法来治疗口腔念珠菌病（通常与生物膜相关）。发生这种情况尤其是由于念珠菌属中耐药性的增加。株。过度使用抗真菌药物，全身毒性，与其他药物的交叉反应性和目前数量低的具有抗真菌活性的药物分子，导致了重要的临床局限性。 我们对用于管理口腔念珠菌病的替代方案进行了重点评估，对同行评审的研究文献进行了书目数据库（PubMed Central，Elsevier的ScienceDirect，SCOPUS和Springer的SpringerLink）的结构化搜索。使用的关键词是“念珠菌病”，“口腔念珠菌病”，“生物膜+念珠菌”，“替代治疗”，“联合疗法+念珠菌”，本综述考虑了最近10至15年的报告。 该综述确定了治疗口腔念珠菌病的几种有前途的新方法：联合抗念珠菌治疗，义齿清洁剂，漱口水作为破坏念珠菌生物膜的替代品，天然化合物（例如蜂蜜，益生菌，植物提取物和精油）和光动力疗法。该评价的结果证实了开发口服念珠菌感染的有效疗法的重要性和紧迫性。
关键词: 念珠菌，口腔念珠菌病，耐药，抗真菌治疗，植物，蜂蜜，益生菌，光动力疗法。
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