Review Article

新偏头痛发现的治疗作用

卷 26, 期 34, 2019

页: [6261 - 6281] 页: 21

弟呕挨: 10.2174/0929867325666180530114534

价格: $65

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摘要

背景:偏头痛是最致残的神经系统疾病之一,并伴有较高的社会经济成本。尽管偏头痛发病机制的某些方面仍未完全了解,但主要假说暗示了三叉神经血管系统激活的作用。 Triptans被认为是当前偏头痛发作的金标准疗法。但是,它们在临床实践中的使用受到限制。预防性治疗包括预防偏头痛的非特异性方法。所有这些都支持对未来研究的需求,以开发创新的抗偏头痛药物。 目的:本研究是对有关偏头痛研究中新疗法的最新文献的综述。 方法:在PUBMED数据库中进行了系统的文献检索,以探讨直至2017年7月发表的偏头痛的治疗策略。 结果:正在进行的5-HT1F受体激动剂和谷氨酸受体拮抗剂的临床试验为急性偏头痛治疗提供了有希望的新方面。抗CGRP和CGRP受体的单克隆抗体在预防性治疗方面具有革命性意义。但是,需要进一步的长期研究以测试其耐受性。临床前研究表明,PACAP和犬尿酸相关治疗取得了积极成果。其他有希望的治疗策略(例如针对TRPV1,P物质,NOS或orexin的治疗策略)在临床试验中未显示出疗效。 结论:由于其副作用,当前的治疗方法并不适合所有偏头痛患者。特别是频繁的发作性和慢性偏头痛代表了研究人员的治疗挑战。需要临床和临床前研究来阐明偏头痛的病理生理学,以便开发新的偏头痛特异性疗法。

关键词: 降钙素基因相关肽,5-HT1F受体激动剂,谷氨酸,垂体腺苷酸环化酶激活多肽,犬尿酸,三叉神经血管系统。

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