1,2,4-Oxadiazole as a Privileged Scaffold for Anti-inflammatory and Analgesic Activities: A Review

Title:1,2,4-Oxadiazole as a Privileged Scaffold for Anti-inflammatory and Analgesic Activities: A Review

Volume: 18 Issue: 18

Author(s): Gita Chawla*

Affiliation:

• Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard (Deemed to be University), Hamdard Nagar, New Delhi-110 062,India

Keywords: 1, 2, 4-Oxadiazole, NSAIDs, COX, anti-inflammatory, analgesic, COX.

Abstract: 1,2,4-Oxadiazole is one of the important heterocycles used by medicinal chemists in designing a new therapeutic molecule. The compounds containing this nucleus are reported to have a wide range of pharmaceutical and biological applications including anti-inflammatory and analgesic activities. The fused and pendent 1,2,4-oxadiazole moiety has been traced in a number of well established, commercially available drugs. This review article provides an up to date information about techniques adopted for the synthesis of 1,2,4-oxadiazoles, and their therapeutic importance as anti-inflammatory and analgesic agents.

Cite this article as:

Chawla Gita *, 1,2,4-Oxadiazole as a Privileged Scaffold for Anti-inflammatory and Analgesic Activities: A Review, Mini-Reviews in Medicinal Chemistry 2018; 18 (18) . https://dx.doi.org/10.2174/1389557518666180524112050