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Review Article

关于多奈哌齐衍生物作为阿尔茨海默氏病潜在胆碱酯酶抑制剂的系统评价

卷 26, 期 30, 2019

页: [5625 - 5648] 页: 24

弟呕挨: 10.2174/0929867325666180517094023

价格: $65

摘要

阿尔茨海默氏病（AD）是一种多因素进行性神经退行性疾病，其特征是记忆力丧失，定向障碍和智力能力逐渐下降。 其病因尚未阐明。 迄今为止，仅一种治疗方法被批准用于治疗AD。 AD的药物治疗依赖于非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂-美金刚和乙酰胆碱酯酶（AChE）抑制剂（AChEIs）-他克林，多奈哌齐，卡巴拉汀和加兰他敏。 多奈哌齐主要通过AChE能够减轻与AD相关的症状，但也可以减轻β-淀粉样蛋白的负担。 这篇综述介绍了与多奈哌齐相关的化合物的概述，这些化合物是在胆碱能假说的基础上开发的潜在抗AD药物，仅用作AChE和丁酰胆碱酯酶（BChE）抑制剂。

关键词: 阿尔茨海默氏病，乙酰胆碱酯酶，丁酰胆碱酯酶，多奈哌齐，抑制剂，治疗，NMDA。

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