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Review Article

环氧合酶-2抑制剂作为炎性疾病的治疗靶标

卷 26, 期 18, 2019

页: [3225 - 3241] 页: 17

弟呕挨: 10.2174/0929867325666180514112124

价格: $65

摘要

炎症在许多复杂疾病和病症的发展中起着至关重要的作用，包括自身免疫性疾病，代谢综合征，神经退行性疾病和心血管疾病。 前列腺素在炎症中起调节作用。 环氧合酶是催化花生四烯酸代谢和前列腺素合成的初始步骤，是炎症的主要介质。 组成型亚型COX-1和诱导型亚型COX-2的差异表达，以及发现COX-1是胃肠道表达的主要形式的发现，导致寻找作为抗炎药的COX-2选择性抑制剂 可能会减轻传统非甾体类抗炎药（NSAID）的胃肠道副作用的药物。 COX-2同工型主要在炎症细胞中表达，并在慢性和急性炎症中明显上调，成为许多药理抑制剂的关键靶标。 COX-2选择性抑制剂碰巧显示出与传统NSAID等效的功效，但它们减少了胃肠道副作用。 这篇综述将阐明选择性COX-2抑制及其与人类病理学相关性的最新发现，特别是在以长期炎症状态为特征的炎性病理中，包括自身免疫性疾病，代谢综合征，肥胖，动脉粥样硬化，神经退行性疾病，慢性阻塞性疾病 肺部疾病，关节炎，慢性炎症性肠病和心血管疾病。

关键词: 环氧合酶，COX抑制剂，炎症，白介素，天然化合物。 前列腺素。

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