摘要
阿尔茨海默病是一种常见于老年人的神经退行性疾病。β-淀粉样蛋白（aβ）斑块和磷酸化tau诱导的神经纤维缠结是本病的两个病理特征，这些特征的相应病理途径被认为是治疗靶点。有许多药物计划用于临床前和临床试验，目的是抑制病理性aβ和tau聚集物的起始物以及tau高磷酸化中的关键aβ分泌酶和激酶。此外，对疾病基因变异的研究以及早期发育中关键预后效应物的检测对AD的控制也很重要。潜在药物靶点的发现有助于以阶段依赖的方式进行靶向治疗，但仍存在一些引起关注的问题，如临床试验报告中候选药物的低生物利用度和低疗效。因此，对候选药物的修改和给药制剂的开发至关重要。随着细胞替代疗法等其他医学进步，在可预见的将来有治愈阿尔茨海默病的希望。
关键词: Aβ聚集，Aβ板，TAU磷酸化，神经纤维矩形，TAU激酶，药物供应，靶向治疗。
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