Abstract
Background: Preeclampsia is a multisystem disorder affecting 5%-8% of pregnant women. Considering the ongoing debate over the predicting value of some commercial first trimester tests, the aim of this study was to compare the existing first-trimester screening tests for preeclampsia.
Methods: In this systematic review, relevant articles published during 2000-2017 were extracted from PubMed, Science Direct, Scopus, Cochrane Library, ISI Web of Science, and ProQuest databases. After a thorough evaluation of the 412 potentially eligible papers, only 28 papers were selected based on the inclusion criteria.
Results: From a total of 412 retrieved studies, 28 papers were found eligible. Most studies had casecontrol or nested case-control designs. A total of 15164 pregnant women were evaluated in the reviewed studies. Various tests were applied in the first trimester of pregnancy to predict the development of preeclampsia. The most commonly used biomarkers were uterine artery pulsatility index, pregnancy-associated plasma protein A (PAPP-A), adiponectin, human chorionic gonadotropin (hCG) hormone and inhibin-A. Other tests were used in only one or two studies.
Conclusion: Based on this review, a combination of markers should be evaluated for the identification of high-risk women. Novel methods measuring multiple markers will hopefully facilitate the development of clinically effective screening programs in the future.
Keywords: Preeclampsia, screening test, first trimester, screening tests, human Chorionic Gonadotropin (hCG) hormone, inhibin-A.
Graphical Abstract
Current Hypertension Reviews
Title:A Systematic Review of First Trimester Biochemical and Molecular Predictive Tests for Preeclampsia
Volume: 14 Issue: 1
Author(s): Fatemeh Abdi, Zohreh Aghaie, Fatemeh Sadat Rahnemaie and Zainab Alimoradi*
Affiliation:
- Social Determinants of Health Research Centre (SDH), Qazvin University of Medical Sciences, Qazvin,Iran
Keywords: Preeclampsia, screening test, first trimester, screening tests, human Chorionic Gonadotropin (hCG) hormone, inhibin-A.
Abstract: Background: Preeclampsia is a multisystem disorder affecting 5%-8% of pregnant women. Considering the ongoing debate over the predicting value of some commercial first trimester tests, the aim of this study was to compare the existing first-trimester screening tests for preeclampsia.
Methods: In this systematic review, relevant articles published during 2000-2017 were extracted from PubMed, Science Direct, Scopus, Cochrane Library, ISI Web of Science, and ProQuest databases. After a thorough evaluation of the 412 potentially eligible papers, only 28 papers were selected based on the inclusion criteria.
Results: From a total of 412 retrieved studies, 28 papers were found eligible. Most studies had casecontrol or nested case-control designs. A total of 15164 pregnant women were evaluated in the reviewed studies. Various tests were applied in the first trimester of pregnancy to predict the development of preeclampsia. The most commonly used biomarkers were uterine artery pulsatility index, pregnancy-associated plasma protein A (PAPP-A), adiponectin, human chorionic gonadotropin (hCG) hormone and inhibin-A. Other tests were used in only one or two studies.
Conclusion: Based on this review, a combination of markers should be evaluated for the identification of high-risk women. Novel methods measuring multiple markers will hopefully facilitate the development of clinically effective screening programs in the future.
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Cite this article as:
Abdi Fatemeh , Aghaie Zohreh, Rahnemaie Sadat Fatemeh and Alimoradi Zainab *, A Systematic Review of First Trimester Biochemical and Molecular Predictive Tests for Preeclampsia, Current Hypertension Reviews 2018; 14 (1) . https://dx.doi.org/10.2174/1573402114666180416160425
DOI https://dx.doi.org/10.2174/1573402114666180416160425 |
Print ISSN 1573-4021 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6506 |
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