Abstract
Background: Portulaca oleracea L. (Purslane) has been used in traditional medicine against hepatic injury, although its actual efficacy has not been fully understood. The present study aimed to critically review the recent literature data from 1990 to 2017 regarding the hepato-protective effects of Portulaca oleracea L. and its underlying mechanisms.
Methods: Online literature resources were checked using different search engines such as Medline, PubMed, Iran Medex, Scopus, and Google Scholar to identify articles, editorials, and reviews about antidotal effects of Portulaca oleracea L. against hepatotoxic agents.
Results: Few studies have indicated that Portulaca oleracea L. shows protective effects against hepatotoxic agents. However, due to lack of information in humans, more studies are needed to confirm the efficacy of Portulaca oleracea L. as a hepato-protective agent.
Conclusion: The study found that Portulaca oleracea L. may be effective on hepatotoxicity by modulating oxidative stress and inflammation.
Keywords: Portulaca oleracea L., liver, hepatotoxic agents, antioxidant, traditional medicine, hepatotoxicity.
Graphical Abstract
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