Graphene Oxide as Scaffolds for Stem Cells: An Overview

Title:Graphene Oxide as Scaffolds for Stem Cells: An Overview

Volume: 17 Issue: 9

Author(s): M. Duran, A.C.M. Luzo, J.G. de Souza, W.J. Favaro*, P. Garcia and N. Duran*

Affiliation:

• Institute of Biology, Urogenital, Carcinogenesis and Immunotherapy Laboratory, Department Genetics, Evolution and Bioagents, University of Campinas, Campinas, SP,Brazil

• NanoBioss-Institute of Chemistry, University of Campinas, Campinas, SP,Brazil

Keywords: Stem cells, graphene oxide, adipose tissue derived mesenchymal stromal/stem cells, topography, differentiation, tissue engineering.

Abstract: Graphene and graphene oxide topography have an effect on the fate of stem cells such as adhesion, differentiation, and proliferation. This overview clearly shows that a new design and manipulation of associated graphene oxide stem cell culture platforms are of paramount importance as a focus in stem cell to tissue engineering applications. This overview also proposes that a film of graphene oxide is an efficient platform to modulate structure and function of multipotent mesenchymal stem/stromal cells (MSCs) and in special human adipose tissue derived mesenchymal stromal/stem cells (AT-MSCs). The implication of graphene oxide on osteogenesis, neurogenesis, oligodendrogenesis, adipogenic and epithelial differentiation is also discussed. Graphene oxide toxicity on stem cells and the importance of GO application on ATMSCs differentiation and proliferation are final topics that are being discussed.

Cite this article as:

Duran M. , Luzo A.C.M., de Souza J.G., Favaro W.J.*, Garcia P. and Duran N. *, Graphene Oxide as Scaffolds for Stem Cells: An Overview, Current Molecular Medicine 2017; 17 (9) . https://dx.doi.org/10.2174/1566524018666180308111915