摘要
越来越多的证据表明,LIM和SH3结构域蛋白1(LASP 1)是一种多功能蛋白,在不同肿瘤细胞骨架形成和预后指标中起着重要作用。LASP 1 e临床标本中的表达与肿瘤的分级、大小和转移有关。LASP 1的上调可能促进肿瘤细胞的增殖、迁移和侵袭。与细胞骨架的相互作用和核易位的增加。LASP 1在肿瘤中的作用机制尚处于初级阶段,因此,各种肿瘤的信号转导途径尚处于起步阶段。本文对LASP 1的生物学研究进行了详细的总结。本文系统地综述了LASP 1在生理学中的贡献的研究现状。L和病理过程,尤其是肿瘤的进展。本文还着重介绍了LASP 1与肿瘤微环境的关系。
关键词: LIM和SH3结构域的蛋白1,肿瘤微环境中,基因转移,核易位,细胞骨架。
Current Molecular Medicine
Title:LASP1 in Tumor and Tumor Microenvironment
Volume: 17 Issue: 8
关键词: LIM和SH3结构域的蛋白1,肿瘤微环境中,基因转移,核易位,细胞骨架。
摘要: The growing evidence shows that LIM and SH3 Domain Protein 1 (LASP1) is a multi-functional protein that plays important role in forming cytoskeleton and prognostic marker in different cancers. LASP1 expression is correlated with the grade, size, and the metastasis of tumor in clinical samples. And the upregulation of LASP1 facilitates tumor cells proliferation, migration, and invasion perhaps through the interaction with cytoskeleton and increased nuclear translocation. The underlying mechanism of LASP1 on tumor is still in the initial stage; therefore, the signaling pathways in various tumors are specifically summarized to deepen the biological understanding of LASP1. This article systematically summarizes the current status of knowledge regarding the contribution of LASP1 in physiological and pathological processes, especially the progress in tumor. This article also gives an emphasized overview of LASP1 on the correlation with tumor microenvironment.
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Cite this article as:
LASP1 in Tumor and Tumor Microenvironment, Current Molecular Medicine 2017; 17 (8) . https://dx.doi.org/10.2174/1566524018666180222115103
DOI https://dx.doi.org/10.2174/1566524018666180222115103 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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