摘要
背景和目的:肿瘤的生长、发展、进展、转移、侵袭和抗药物抵抗力完全取决于周围细胞、细胞外基质和肿瘤细胞的聚集。或微环境(TME)。TME与肿瘤相关成纤维细胞(CAF)直接或间接相关.CAF与肿瘤周围细胞的相互作用及其起源、活化关于肿瘤的转化和吸收其他非肿瘤细胞的能力,长期以来都是非常复杂和活跃的研究课题。本研究对CAF与HEAF的研究作了深入的回顾。阐明其调节TME的潜在靶点,并在临床试验中讨论目前的药物,通过CAF进行靶向治疗。 结论:caf在抗肿瘤治疗中的潜在作用在于其对药物的一致反应,通过这些基因上更稳定的抗免疫支持来针对不同的肿瘤部位。多孔的咖啡馆细胞。CAF可通过免疫系统;生长因子(GF)包括转化生长因子(TGF)、血管内皮生长因子(GF)、成纤维细胞生长因子(GF)、血小板衍生生长因子(GF)和TME等。包括缺氧、碳酸氢酶、细胞外基质(ECM)。总的来说,caf的这些特性使得它最容易受到单一和联合抗肿瘤治疗的影响。本征效应或加性效应。CAF的潜在活性、起源机制和精细生物标记的鉴定还有待进一步研究。关于他们的令人振奋的事实双方期望通过包括临床前和临床在内的各级进步研究的CAFs来建立新的癌症治疗机构。铝的试验以及具有很大的潜力,有待进一步探讨。
关键词: 肿瘤微环境,缺氧,协同效应,遗传稳定性,生物标志物,耐药,抗免疫支持。
图形摘要
Current Drug Targets
Title:Versatility of Cancer Associated Fibroblasts: Commendable Targets for Anti-tumor Therapy
Volume: 19 Issue: 13
关键词: 肿瘤微环境,缺氧,协同效应,遗传稳定性,生物标志物,耐药,抗免疫支持。
摘要: Background and Objective: Tumor growth, development, progression, metastasis, invasion and resistivity against drugs solely depend on the recruitment of surrounding cells, extracellular matrix and Tumor Microenvironment (TME). TME is directly as well as indirectly associated with Cancer- Associated Fibroblasts (CAF). The interactions of CAF with tumor surrounding cells, their origination, activation, transformation and ability to recruit other non-tumor cells for the clemency of tumor, are very complex and under active research since long. This study provides an in-depth review of CAF and highlights its potential targets for the regulation of TME as well as discusses current drugs in clinical trials, targeting through CAF.
Conclusion: The potential role of CAF in anti-tumor therapy is based on its coherent response against drugs, targeting different tumor sections through these genetically more stable and anti-immunosupportive CAF cells. CAF can be targeted through immunity system; Growth Factors (GF) including Transforming growth factor (TGF), vascular endothelial GF, fibroblast GF, platelet derived GF; and TME elements including hypoxia, carbonic anhydrase, extracellular matrix (ECM). Collectively these features of CAF make it most vulnerable against single as well as combinational, anti-tumor therapy for synergistic or additive effects. Potential activities of CAF, their origination mechanisms and identification of meticulous bio-markers are needed to be investigated further. The rousing facts about them mutually culminate the anticipation of progress towards novel therapeutic establishment against cancer through CAFs that are under progressive research at all levels including, pre-clinical and clinical trials as well as possess much potential to be explored further.
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Versatility of Cancer Associated Fibroblasts: Commendable Targets for Anti-tumor Therapy, Current Drug Targets 2018; 19 (13) . https://dx.doi.org/10.2174/1389450119666180219124439
DOI https://dx.doi.org/10.2174/1389450119666180219124439 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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