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Review Article

ER氨肽酶1和2的抑制剂：从设计到临床应用

卷 26, 期 15, 2019

页: [2715 - 2729] 页: 15

弟呕挨: 10.2174/0929867325666180214111849

价格: $65

摘要

内质网氨肽酶1和2是两种同源酶，其有助于产生肽配体以供主要组织相容性I类分子呈递。 它们的酶活性影响抗原肽库并间接控制适应性免疫应答。 越来越多的证据表明，这两种酶是免疫反应调节的易处理靶点，可能的应用范围从癌症免疫治疗到治疗炎症性自身免疫疾病。 在这里，我们回顾了ERAP1和ERAP2抑制剂开发的最新技术，以及它们在临床应用中的潜力和局限性。

关键词: 免疫系统，抗原，肽，酶，抑制剂，癌症，自身免疫，感染。

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