摘要
在已故供者中,缺血/再灌注损伤(IRI)是导致移植肾功能障碍的重要原因。长时间的冷和热缺血时间会导致移植后早期并发症的高风险,包括急慢性排斥反应。缺血不仅能上调炎症细胞因子和趋化因子,还能促进mhc-Ⅱ类和粘附分子在上皮和上皮上的表达。树突状细胞。此外,应激或死亡细胞释放出的危险相关分子模式(DAMP)不仅会引起或放大组织炎症,并在反应t中触发组织修复。OIRI,同时也是增强DC成熟和增强适应性免疫反应的佐剂。在这次检讨中,我们亦会讨论捐赠区或接受区议会在缺血过程增强了急性排斥反应。
关键词: 树突状细胞,肾移植,同种异体排斥反应,缺血/再灌注损伤,APC,CTL。
Current Gene Therapy
Title:How Do Dendritic Cells Play the Role in Ischemia/Reperfusion Triggered Kidney Allograft Rejection
Volume: 17 Issue: 6
关键词: 树突状细胞,肾移植,同种异体排斥反应,缺血/再灌注损伤,APC,CTL。
摘要: In deceased donors, Ischemia/Reperfusion Injury (IRI) is an important cause of allograft dysfunction. Prolonged cold and warm ischemia time leads to a high risk of early post-transplant complications, including acute and chronic rejection. Ischemia not only up-regulates inflammatory cytokines and chemokines, but also enhances the expression of MHC-class II and adhesion molecules on epithelial and dendritic cells. Moreover, the Danger Associated Molecular Patterns (DAMPs) released from stressed or dying cells, not only cause or amplify tissue inflammation and trigger tissue repair in response to IRI, but also act as adjuvants that enhance DC maturation and potentiate the adaptive immune response. In this review, we will also discuss about whether donor or recipient DCs are more important in the process of ischemia enhanced acute rejection.
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How Do Dendritic Cells Play the Role in Ischemia/Reperfusion Triggered Kidney Allograft Rejection, Current Gene Therapy 2017; 17 (6) . https://dx.doi.org/10.2174/1566523218666180214095956
DOI https://dx.doi.org/10.2174/1566523218666180214095956 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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