摘要
背景与目的:白介素37(IL-37)是一种抗炎t细胞反应的重要调节器。在这项研究中,我们研究了它的表达和功能在外周血单核细胞(PBMCs)HLA-B27相关急性前葡萄膜炎患者和特发性AAU(AAU)。方法:15 HLA-B27-associated AAU患者,10特发性AAU患者和22控制招募本研究从2013年8月到2016年12月。完整的眼科检查和临床特征显然是记录。血液样本收集和提取外周血单核细胞。IL-37信使核糖核酸(mRNA)和蛋白表达在外周血单核细胞(PBMCs)被执行rt - pcr和免疫印迹检测,分别。上层清液的细胞因子刺激树突细胞(dc)IL-37被多路复用免疫测定化验。结果:IL-37 mRNA和蛋白表达水平的增加PBMCs被发现在病人组与临床积极AAU相比控制。没有显著差异IL-37 mRNA和蛋白表达水平之间HLA-B27 AAU和特发性AAU有关。IL-37显著抑制生产IL-1β、il - 6、il - 10,IL-21,IL-23,TNF-αIFN-γ。IL-37 mRNA和蛋白表达水平与疾病活动呈显著正相关。结论:高架IL-37表达式与疾病相关联活动HLA-B27 AAU和特发性AAU有关。在AAU IL-37可以抑制促炎细胞因子产品。操纵IL-37可能为这些实体提供一个新的治疗目标。
关键词: 急性前葡萄膜炎、IL-37、细胞因子、HLA-B27特发性AAU PBMC。
Current Molecular Medicine
Title:Elevated Interleukin 37 Expression Associated With Disease Activity in HLA-B27 Associated Anterior Uveitis and Idiopathic Anterior Uveitis
Volume: 17 Issue: 7
关键词: 急性前葡萄膜炎、IL-37、细胞因子、HLA-B27特发性AAU PBMC。
摘要: Background & Objective: Interleukin 37 (IL-37) is an important regulator of the anti-inflammatory T-cell response. In this study, we investigated its expression and function in peripheral blood mononuclear cells (PBMCs) of patients with HLA-B27 associated acute anterior uveitis (AAU) and idiopathic AAU.
Methods: 15 patients with HLA-B27-associated AAU, 10 patients with idiopathic AAU and 22 controls were recruited to this study from August 2013 to December 2016. Complete ophthalmological examinations were performed and clinical features were clearly documented. Blood samples were collected and peripheral blood mononuclear cells were extracted. IL-37 messenger RNA (mRNA) and protein expression in peripheral blood mononuclear cells (PBMCs) were examined by performing RT-PCRs and western blot, respectively. Cytokines in the supernatants of stimulated dendritic cells (DCs) with IL-37 were assayed by multiplex immunoassay.
Results: An increased level of IL-37 mRNA and protein expression by PBMCs was found in the patient group with clinically active AAU compared to controls. There was no significant difference in IL-37 mRNA and protein expression levels between HLA-B27 associated AAU and idiopathic AAU. IL-37 significantly inhibited the production of IL-1β, IL-6, IL-10, IL-21, IL-23, TNF-α and IFN-γ. IL-37 levels of mRNA and protein expression showed a significant positive correlation with disease activity.
Conclusions: Elevated IL-37 expression is associated with disease activity in HLA-B27 associated AAU and idiopathic AAU. IL-37 can inhibit proinflammatory cytokine productions in AAU. Manipulation of IL-37 may offer a new therapeutic target for these entities.
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Cite this article as:
Elevated Interleukin 37 Expression Associated With Disease Activity in HLA-B27 Associated Anterior Uveitis and Idiopathic Anterior Uveitis, Current Molecular Medicine 2017; 17 (7) . https://dx.doi.org/10.2174/1566524018666180207152941
DOI https://dx.doi.org/10.2174/1566524018666180207152941 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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