摘要
背景:越来越多的研究表明维生素E通常具有骨保护作用。然而,本系统综述讨论了一组维生素E异构体,生育三烯酚在通过破骨细胞分化和活性抑制来预防骨质流失方面的作用。 目的:本综述旨在讨论报道生育三烯酚对破骨细胞影响的文献,破骨细胞是专门用于吸收骨骼的细胞。结果:在文献检索的22项研究中,只有11项被确定为相关,其中包括8项动物研究,2项体外研究和仅两项的组合。体内研究表明,生育三烯酚通过抑制破骨细胞形成和再吸收活性来改善骨骼健康并减少骨质流失,这可以通过调节RANKL和OPG表达从血清中的水平看。来自体外研究的数据很好地支持了这一点,该数据表明在用生育三烯酚异构体处理后抑制破骨细胞形成和再吸收活性。 结论:因此,生育三烯酚被认为是潜在的抗氧化剂,用于预防和治疗以骨质流失增加为特征的骨相关疾病
关键词: 破骨细胞,生育三烯酚,骨质流失,抗氧化剂,成骨细胞,破骨细胞。
图形摘要
Current Drug Targets
Title:Tocotrienols Regulate Bone Loss through Suppression on Osteoclast Differentiation and Activity: A Systematic Review
Volume: 19 Issue: 9
关键词: 破骨细胞,生育三烯酚,骨质流失,抗氧化剂,成骨细胞,破骨细胞。
摘要: Background: There are accumulating studies reporting that vitamin E in general exhibits bone protective effects. This systematic review, however discusses the effects of a group of vitamin E isomers, tocotrienols in preventing bone loss through osteoclast differentiation and activity suppression.
Objective: This review is aimed to discuss the literature reporting the effects of tocotrienols on osteoclasts, the cells specialized for resorbing bone.
Results: Out of the total 22 studies from the literature search, only 11 of them were identified as relevant, which comprised of eight animal studies, two in vitro studies and only one combination of both. The in vivo studies indicated that tocotrienols improve the bone health and reduce bone loss via inhibition of osteoclast formation and resorption activity, which could be through regulation of RANKL and OPG expression as seen from their levels in the sera. This is well supported by data from the in vitro studies demonstrating the suppression of osteoclast formation and resorption activity following treatment with tocotrienol isomers.
Conclusion: Thus, tocotrienols are suggested to be potential antioxidants for prevention and treatment of bone-related diseases characterized by increased bone loss.
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Cite this article as:
Tocotrienols Regulate Bone Loss through Suppression on Osteoclast Differentiation and Activity: A Systematic Review, Current Drug Targets 2018; 19 (9) . https://dx.doi.org/10.2174/1389450119666180207092539
DOI https://dx.doi.org/10.2174/1389450119666180207092539 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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