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Current Vascular Pharmacology

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ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

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Review Article

Novel Direct Anticoagulants and Atherosclerosis

Author(s): Andrej Fabjan* and Fajko F. Bajrović

Volume 17, Issue 1, 2019

Page: [29 - 34] Pages: 6

DOI: 10.2174/1570161116666180206111217

Price: $65

Abstract

Coagulation factors can affect cellular processes that include inflammatory signaling by acting on endothelial protease activated receptors, vascular smooth muscle and inflammatory cells beyond the coagulation cascade. This is important in the pathogenesis of atherosclerosis. Accordingly, experimental data points to beneficial effects of coagulation protease inhibitors on the attenuation of atherosclerosis progression in animal models. However, available clinical data do not support the use of anticoagulants as an add-on treatment of atherosclerosis. New clinical studies are needed with a better selection of patients to clarify the role of novel direct anticoagulants in the management of atherosclerosis.

Keywords: Atherosclerosis, coagulation factors, thrombin, activated factor X, direct anticoagulants, SMC.

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