Review Article

肺动脉高压治疗的新药、治疗策略及未来发展方向

卷 26, 期 16, 2019

页: [2844 - 2864] 页: 21

弟呕挨: 10.2174/0929867325666180201095743

价格: $65

摘要

尽管最近在肺动脉高压(PAH)治疗方面取得了进展,但这种病症仍然具有极差的预后。 在这篇综述中,我们讨论了新批准的PAH治疗药物的使用,其中已知的作用机制(macitentan),创新靶点(riociguat和selexipag),以及初始前期联合治疗的新型治疗方法。 其次,我们描述了新的潜在信号通路和研究药物,在治疗PAH方面具有良好的作用。

关键词: 肺动脉高压,macitentan,riociguat,selexipag,初始联合治疗,基因治疗,血清素,炎症,免疫,新陈代谢,肺动脉去神经支配。

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