摘要
背景:FOXP2是forkhead box P(FOXP)家族的成员,据报道在乳腺癌中很重要。然而,其确切的机制和途径仍不清楚。目的:探讨FOXP2对三阴性乳腺癌(TNBC)肿瘤增殖和转移的影响及其分子机制。 方法:我们首先使用qRT-PCR检测TNBC细胞系和组织中的FOXP2表达。然后我们进行细胞增殖测定,集落形成测定和transwell测定以分析FOXP2在TNBC细胞中的表达的作用。进行小鼠异种移植模型以进一步证实FOXP2在TNBC中的作用。此外,我们使用qRT-PCR和Western印迹来获得FOXP2对GRP78表达的作用和qRT-PCR以分析GRP78在TNBC组织中的表达。我们进行了IHC分析以检测移植肿瘤中的FOXP2和GRP78表达,并使用相关分析进一步分析它们之间的关联。 结果:发现FOXP2在TNBC细胞系和组织中高度表达。 FOXP2敲低减弱了体外TNBC的生长和侵袭以及体内肿瘤进展和转移。此外,FOXP2敲减在TNBC细胞和移植肿瘤中下调葡萄糖调节的分子量为78的蛋白质(GRP78)表达。相关分析显示,GRP78的表达与TNBC细胞中FOXP2的表达呈正相关。 结论:FOXP2在TNBC中起关键作用,部分是通过调节GRP78,并可作为TNBC治疗的潜在靶点.
关键词: FOXP2,三阴性乳腺癌,增殖,转移,肿瘤.FOXP2,三阴性乳腺癌,增殖,转移,肿瘤。
图形摘要
Current Cancer Drug Targets
Title:FOXP2 Promotes Tumor Proliferation and Metastasis by Targeting GRP78 in Triple-negative Breast Cancer
Volume: 18 Issue: 4
关键词: FOXP2,三阴性乳腺癌,增殖,转移,肿瘤.FOXP2,三阴性乳腺癌,增殖,转移,肿瘤。
摘要: Background: FOXP2, a member of the forkhead box P (FOXP) family, has been reported to be important in breast cancer. However, its exact mechanisms and pathways remain unclear.
Objective: To investigate the effect of FOXP2 on tumor proliferation and metastasis in triplenegative breast cancer (TNBC) and study its underlying molecular mechanism.
Methods: We first used qRT-PCR to detect FOXP2 expression in TNBC cell lines and tissues. Then we conducted cell proliferation assays, colony formation assays, and transwell assays to analyze the effects of FOXP2 expression in TNBC cells. Mouse xenograft model was performed to further confirm the role of FOXP2 in TNBC. Moreover, we used qRT-PCR and Western blot to access the effect of FOXP2 on GRP78 expression and qRT-PCR to analyze GRP78 expression in TNBC tissues. We conducted IHC analysis to detect both FOXP2 and GRP78 expressions in transplanted tumors and used the correlation analysis to further analyze the link between them.
Results: FOXP2 was found to be highly expressed in TNBC cell lines and tissues. FOXP2 knockdown attenuated the growth and invasiveness of TNBC in vitro as well as tumor progression and metastasis in vivo. Moreover, FOXP2 knockdown downregulated glucose-regulated protein of molecular mass 78 (GRP78) expression in TNBC cells and transplanted tumors. Correlation analysis showed that GRP78 expression was positively associated with FOXP2 expression in TNBC cells.
Conclusion: FOXP2 plays a crucial role in TNBC, partly through modulating GRP78, and could act as a potential target for TNBC treatment.
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Cite this article as:
FOXP2 Promotes Tumor Proliferation and Metastasis by Targeting GRP78 in Triple-negative Breast Cancer, Current Cancer Drug Targets 2018; 18 (4) . https://dx.doi.org/10.2174/1568009618666180131115356
DOI https://dx.doi.org/10.2174/1568009618666180131115356 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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