摘要
研究背景:过氧化物酶体增殖物受体γ(peroxinalgrowatorreceptor,γ)是一类参与胰岛素敏感的核激素受体家族。此外,PPARγ通过调节NFkappaB水平和与Nrf 2通路的串扰,在保护氧化应激和炎症中发挥关键作用。此外,它在调节免疫反应的作用是实质性的。目的:辐射诱导的氧化应激是导致造血、胃肠系统损伤和免疫系统抑制的唯一决定因素。在放射治疗过程中不受控制地暴露在正常细胞中,这就增加了对新型高效放射防护装置的需求。在这篇综述中,我们将概述pPARγ在辐射损伤和炎症中的参与,重点是pPARγ是否可以作为一个合适的放射染色靶点。结论:PPARγ既具有放射防护作用,又具有放射治疗潜力,为开发新的、更有效的治疗方法提供了一个有吸引力的靶点。
关键词: PPARγ,氧化应激,放射,癌症,NFkappaB,炎症。
图形摘要
Current Drug Targets
Title:PPARγ-targeting Potential for Radioprotection
Volume: 19 Issue: 15
关键词: PPARγ,氧化应激,放射,癌症,NFkappaB,炎症。
摘要: Background: Peroxisomal proliferator receptor gamma (PPARγ) is a class of nuclear hormone receptor family involved in insulin sensitization. In addition, PPARγ has a key role in the protection against oxidative stress and inflammation through regulation of NFkappaB levels and crosstalk with the Nrf2 pathway. Also, its role in the modulation of immune response is substantial.
Objective: Radiation-induced oxidative stress is the sole determinant of damage to hematopoietic, gastrointestinal system and immune system suppression. Uncontrolled exposure to normal cells during radiotherapy raises the demand for novel and efficient radioprotectors. In this review, we will present an overview of the involvement of PPARγ in radiation-induced damage and inflammation with major emphasis on whether PPARγ can serve as a suitable radiomodification target.
Conclusion: Through this review, we have justified that PPARγ having both radioprotective as wells as radiotherapeutic potential, may serve as an attractive target for the development of novel and more effective therapies.
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Cite this article as:
PPARγ-targeting Potential for Radioprotection, Current Drug Targets 2018; 19 (15) . https://dx.doi.org/10.2174/1389450119666180131105158
DOI https://dx.doi.org/10.2174/1389450119666180131105158 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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