摘要
研究背景:过氧化物酶体增殖物受体γ(peroxinalgrowatorreceptor,γ)是一类参与胰岛素敏感的核激素受体家族。此外,PPARγ通过调节NFkappaB水平和与Nrf 2通路的串扰,在保护氧化应激和炎症中发挥关键作用。此外,它在调节免疫反应的作用是实质性的。目的:辐射诱导的氧化应激是导致造血、胃肠系统损伤和免疫系统抑制的唯一决定因素。在放射治疗过程中不受控制地暴露在正常细胞中,这就增加了对新型高效放射防护装置的需求。在这篇综述中,我们将概述pPARγ在辐射损伤和炎症中的参与,重点是pPARγ是否可以作为一个合适的放射染色靶点。结论:PPARγ既具有放射防护作用,又具有放射治疗潜力,为开发新的、更有效的治疗方法提供了一个有吸引力的靶点。
关键词: PPARγ,氧化应激,放射,癌症,NFkappaB,炎症。
图形摘要
Current Drug Targets
Title:PPARγ-targeting Potential for Radioprotection
Volume: 19 Issue: 15
关键词: PPARγ,氧化应激,放射,癌症,NFkappaB,炎症。
摘要: Background: Peroxisomal proliferator receptor gamma (PPARγ) is a class of nuclear hormone receptor family involved in insulin sensitization. In addition, PPARγ has a key role in the protection against oxidative stress and inflammation through regulation of NFkappaB levels and crosstalk with the Nrf2 pathway. Also, its role in the modulation of immune response is substantial.
Objective: Radiation-induced oxidative stress is the sole determinant of damage to hematopoietic, gastrointestinal system and immune system suppression. Uncontrolled exposure to normal cells during radiotherapy raises the demand for novel and efficient radioprotectors. In this review, we will present an overview of the involvement of PPARγ in radiation-induced damage and inflammation with major emphasis on whether PPARγ can serve as a suitable radiomodification target.
Conclusion: Through this review, we have justified that PPARγ having both radioprotective as wells as radiotherapeutic potential, may serve as an attractive target for the development of novel and more effective therapies.
Export Options
About this article
Cite this article as:
PPARγ-targeting Potential for Radioprotection, Current Drug Targets 2018; 19 (15) . https://dx.doi.org/10.2174/1389450119666180131105158
DOI https://dx.doi.org/10.2174/1389450119666180131105158 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Sex, Stress and their Influence on Respiratory Regulation
Current Pharmaceutical Design The Role of the RhoA/rho-kinase Pathway in Pulmonary Hypertension
Current Drug Discovery Technologies Choline Alphoscerate (Alpha-Glyceryl-Phosphoryl-Choline) An Old Choline- containing Phospholipid with a Still Interesting Profile As Cognition Enhancing Agent
Current Alzheimer Research Fatal Lactic Acidosis Precipitated by Nifedipine in a Patient Treated with Disulfiram and Antiretrovirals
Drug Metabolism Letters The Application of NMR Spectroscopy for the Study of Heart Failure
Current Pharmaceutical Design Low Baseline Urine Creatinine Excretion Rate Predicts Poor Outcomes among Critically Ill Acute Stroke Patients
Current Neurovascular Research Disease Modification in Rheumatoid Arthritis and Osteoarthritis-Current and Emerging Targets and Therapeutics
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Cellular Mechanisms of Brain Injury and Cell Death
Current Pharmaceutical Design Atenolol: Differences in Mode of Action Compared with other Antihypertensives.An Opportunity to Identify Features that Influence Outcome?
Current Pharmaceutical Design Pomolic Acid Isolated from the Leaves of Licania pittieri Inhibits ADP-and Epinephrine-Induced Platelet Aggregation and has Hypotensive Effect on Rats
Current Bioactive Compounds Update on the Pharmacological Treatment of Alzheimers Disease
Current Neuropharmacology Prevention of Bronchopulmonary Dysplasia
Current Pediatric Reviews Determinants of Progression in Early Autosomal Dominant Polycystic Kidney Disease: Is it Blood Pressure or Renin-Angiotensin-Aldosterone-System Blockade?
Current Hypertension Reviews A<sub>3</sub> Adenosine Receptor: A Plausible Therapeutic Target for Cardio-Protection in Diabetes
Recent Patents on Cardiovascular Drug Discovery Ruptured Renal Artery Aneurysm: Successful Endovascular Therapy with Stent-Graft Placement
Current Medical Imaging High Fat Meal Increase of IL-17 is Prevented by Ingestion of Fruit Juice Drink in Healthy Overweight Subjects
Current Pharmaceutical Design Circulatory Estrogen Level Protects Against Breast Cancer in Obese Women
Recent Patents on Anti-Cancer Drug Discovery Leptin in Thrombosis and Atherosclerosis
Current Pharmaceutical Design Influence of ABCB1 Gene Polymorphisms and P-Glycoprotein Activity on Cyclosporine Pharmacokinetics in Peripheral Blood Mononuclear Cells in Healthy Volunteers
Drug Metabolism Letters Sympathetic Activation in Hypertension and in Hypertension-Related Metabolic Disease
Current Hypertension Reviews