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General Review Article

血液凝固级联：洞察生命因素Xa

卷 26, 期 17, 2019

页: [3175 - 3200] 页: 26

弟呕挨: 10.2174/0929867325666180125165340

价格: $65

摘要

因子Xa（FXa）在止血中起关键作用，它是血液凝固级联的中心部分，其催化凝血酶的产生并导致凝块形成和伤口闭合。 因此，FXa是开发新抗凝剂的有吸引力的目标。 在这篇综述中，我们将首先描述这种基础蛋白的分子特征，以了解其作用机制，这是通过合成有机化学或使用从重组方法获得的肽设计新型抑制剂的必要背景。 然后，我们将回顾新型直接FXa抑制剂合成的现状及其作用机制。 最后，还将讨论通过使用这些批准的商业药物来帮助维持血液止血的逆转剂。

关键词: 凝血级联，抗凝血剂，FXa，合成抑制剂，直接FXa抑制剂，FXa逆转剂。

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