摘要
背景:脂肪组织作为甘油三酯(TGS)在储存多余的能量中起着重要的作用,过多的脂肪积累会引起各种代谢和心血管疾病。据报道,非脂肪组织中的异位脂肪沉积和TG过量积累可能是心血管代谢和血管危险的重要预测因子,例如,血管周围组织中的异位脂肪促进动脉壁动脉粥样硬化斑块的形成。 目的:近年来报道腹主动脉瘤(AAA)血管壁内的异位脂肪(脂肪细胞)在人和实验动物模型中均有存在,其病理意义尚未完全阐明,本文综述了脂肪细胞的功能,并探讨了靶向血管脂肪细胞治疗AAA的新药物。 结论:血管壁脂肪细胞可能是AAA治疗药物开发的新靶点。
关键词: 脂肪细胞,甘油三酯,异位脂肪,腹主动脉瘤,破裂,血管疾病。
图形摘要
Current Drug Targets
Title:Adipocytes and Abdominal Aortic Aneurysm: Putative Potential Role of Adipocytes in the Process of AAA Development
Volume: 19 Issue: 11
关键词: 脂肪细胞,甘油三酯,异位脂肪,腹主动脉瘤,破裂,血管疾病。
摘要: Background: Adipose tissue plays a role in the storage of excess energy as triglycerides (TGs). Excess fat accumulation causes various metabolic and cardiovascular diseases. It has been reported that ectopic fat deposition and excess TG accumulation in non-adipose tissue might be important predictors of cardiometabolic and vascular risk. For example, ectopic fat in perivascular tissue promotes atherosclerotic plaque formation in the arterial wall.
Objective: Recently, it has been reported that ectopic fat (adipocyte) in the vascular wall of an abdominal aortic aneurysm (AAA) is present in both human and experimental animal models. The pathological significance of adipocytes in the AAA wall has not been fully understood. In this review, we summarized the functions of adipocytes and discussed potential new drugs that target vascular adipocytes for AAA treatment.
Result: Previous studies suggest that adipocytes in vascular wall play an important role in the development of AAA.
Conclusion: Adipocytes in the vascular wall could be novel targets for the development of AAA therapeutic drugs.
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Cite this article as:
Adipocytes and Abdominal Aortic Aneurysm: Putative Potential Role of Adipocytes in the Process of AAA Development, Current Drug Targets 2018; 19 (11) . https://dx.doi.org/10.2174/1389450119666180115164103
DOI https://dx.doi.org/10.2174/1389450119666180115164103 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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