Abstract
Organocatalyzed (4+2) cycloadditions (Diels-Alder reactions) are reviewed in this manuscript. Among the different catalytic alternatives, reactions involving α,β-unsaturated ketones and alkenes are considered. In these processes, substituted cyclohexanones are obtained via HOMO activation generated by amine organocatalysis that generate transient dienamine species. Both concerted and stepwise mechanisms are described. In most cases, excellent regio-, diastereo- and enantiocontrol have been observed.
Keywords: Organocatalysis, diels-Alder reactions, cycloadditions, michael additions, pericyclic reactions, stepwise mechanisms.
Graphical Abstract
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