Synthesis of Secondary Phosphine Oxides by Substitution at Phosphorus by Grignard Reagents

Title:Synthesis of Secondary Phosphine Oxides by Substitution at Phosphorus by Grignard Reagents

Volume: 15 Issue: 5

Author(s): Anna Tripolszky and Gyorgy Keglevich*

Affiliation:

• Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest,Hungary

Keywords: Dialkyl phosphites, grignard reagents, P(III)-chlorides, secondary phosphine oxides, substitution, ligand.

Abstract: Secondary phosphine oxides (SPOs) are important starting materials in organophosphorus syntheses, and may be the ligands in transition metal complexes. SPOs are obtained from phosphorus trichloride via double substitution by a Grignard reagent followed by hydrolysis, or from dialkyl phosphites by reaction with two equivalents of a Grignard reagent. The preparation of SPOs with two different substituents is of special importance. This minireview gives useful hints for the synthesis of a variety of SPOs that are useful intermediates.

Cite this article as:

Tripolszky Anna and Keglevich Gyorgy *, Synthesis of Secondary Phosphine Oxides by Substitution at Phosphorus by Grignard Reagents, Letters in Organic Chemistry 2018; 15 (5) . https://dx.doi.org/10.2174/1570178615666171227144555