摘要
背景:子宫内膜是最重要的女性生殖器官之一。多囊卵巢综合征(PCOS)是影响育龄妇女的生殖和内分泌病理。 PCOS负面影响子宫内膜,导致植入失败和增殖性畸变。 方法:我们使用以下关键词在http://www.ncbi.nlm.nhi.gov/pubmed/electronic数据库中进行了搜索:子宫内膜类固醇受体,子宫内膜,子宫功能,子宫内膜和PCOS,植入窗,植入和PCOS,植入标志物,炎症,氧化应激。我们根据他们的标题和摘要选择文章,然后根据本文所提供的信息对全文进行分析并对文章进行分类。 结果:PCOS妇女的内分泌和代谢异常促进了对子宫内膜的复杂影响,导致植入率甚至不育。具有PCOS的女性在下丘脑 - 垂体 - 卵巢轴中表现出改变,导致雌激素的循环水平不变,类似于早期卵泡期,并且雌激素和黄体酮的停止不足。除了这种雌激素和孕激素停用的不足之外,胰岛素/葡萄糖途径,粘附分子,细胞因子和炎症级联以及促氧化状态的建立导致子宫功能失调,这又导致到植入失败甚至子宫内膜癌。 结论:PCOS女性显示下丘脑 - 垂体 - 卵巢轴失调,改变了类固醇途径。另外,子宫内膜中雌激素和孕激素停用的不足导致子宫内膜细胞增殖异常。在PCOS患者中观察到的脂肪组织的不平衡增强了循环激素的增加。目前的综述描述了激素,代谢产物,细胞因子,粘附分子和与PCOS妇女子宫内膜相关的胰岛素/葡萄糖途径的作用及其在子宫内膜癌的种植失败和发展中的作用。
关键词: 多囊卵巢综合征,子宫内膜,孕酮,雌二醇,雄激素,胰岛素,葡萄糖,脂肪因子,粘附分子。
Current Medicinal Chemistry
Title:Uterine Function: From Normal to Polycystic Ovarian Syndrome Alterations
Volume: 25 Issue: 15
关键词: 多囊卵巢综合征,子宫内膜,孕酮,雌二醇,雄激素,胰岛素,葡萄糖,脂肪因子,粘附分子。
摘要: Background: The endometrium is one of the most important female reproductive organs. Polycystic ovarian syndrome (PCOS) is a reproductive and endocrine pathology that affect women of reproductive age. PCOS negatively affects the endometrium, leading to implantation failure and proliferative aberrations.
Methods: We conducted a search at the http://www.ncbi.nlm.nhi.gov/pubmed/electronic database using the following key words: endometrial steroid receptors, endometrium, uterine function, endometrium and PCOS, implantation window, implantation and PCOS, implantation markers, inflammation, oxidative stress. We selected the articles based on their titles and abstracts, then we analyzed the full text and classified the articles depending on the information provided according to the sections of the present review.
Results: The endocrine and metabolic abnormalities displayed in women with PCOS promote complex effects on the endometrium, leading to a low rate of implantation and even infertility. Women with PCOS show alterations in the Hypothalamic-Pituitary- Ovarian axis, which results in constant circulating levels of estrogen, similar to those at the early follicular phase, and a deficiency in the withdrawal of estrogen and progesterone. Besides this deficiency in the withdrawal of estrogen and progesterone, the insulin/ glucose pathway, adhesion molecules, cytokines and the inflammatory cascade, together with the establishment of a pro-oxidative status, lead to an imbalance in the uterine function, which in turn leads to implantation failure or even endometrial cancer.
Conclusion: Women with PCOS display a dysregulation of the Hypothalamic-Pituitary- Ovarian axis, which alters the steroid pathway. In addition, the deficiency in the withdrawal of estrogen and progesterone in the endometrium results in abnormal endometrial cellular proliferation. The imbalance in adipose tissue observed in PCOS patients reinforces the increase in circulating hormones. The present review describes the role of hormones, metabolites, cytokines, adhesion molecules and the insulin/glucose pathway related to the uterine endometrium in women with PCOS and their role in implantation failure and development of endometrial cancer.
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Cite this article as:
Uterine Function: From Normal to Polycystic Ovarian Syndrome Alterations, Current Medicinal Chemistry 2018; 25 (15) . https://dx.doi.org/10.2174/0929867325666171205144119
DOI https://dx.doi.org/10.2174/0929867325666171205144119 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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