摘要
胶质瘤相关基因(Glis)是典型的Hedgehog(HH)信号通路的锌指蛋白家族成员和下游调控因子。Gli蛋白对生长发育的影响生物体的修复和组织修复的帮助。然而,GLI家族成员GLI1的异常表达通过诱导上皮-间充质转化(EMT)、血管生成和O促进癌变。信号通路。GLI 1的过表达被认为是预后不良的一个指标,也是治疗癌症的潜在靶点。Gli抑制剂,如0.0 1,Gnt 61,Resvera在体外和体内肿瘤研究中,环戊胺抑制HH通路,其他非典型途径也可能激活GLI 1的表达。在这里,我们总结了GLI在致癌物质中的作用。SIS和癌症靶向治疗。
关键词: 刺猬信号,GLI蛋白,致癌,靶向治疗,非典型途径,突变。
图形摘要
Current Cancer Drug Targets
Title:Role of Glioma-associated GLI1 Oncogene in Carcinogenesis and Cancertargeted Therapy
Volume: 18 Issue: 6
关键词: 刺猬信号,GLI蛋白,致癌,靶向治疗,非典型途径,突变。
摘要: Glioma-associated oncogenes (GLIs) are zinc finger protein family members and downstream regulatory factors of the classic Hedgehog (Hh) signaling pathway. GLI proteins influence the growth and development of organisms and aid in tissue repair. However, aberrant expression of the GLI family member GLI1 promotes carcinogenesis by inducing epithelial–mesenchymal transition (EMT), angiogenesis, and other signaling pathways. Overexpression of GLI1 is thought to be an indicator of poor prognosis as well as a potential therapeutic target for cancers. GLI inhibitors such as zerumbone, GANT61, resveratrol, and cyclopamine depress the Hh pathway in vitro and in vivo cancer research, and other non-canonical pathways may also activate expression of GLI1. Here, we summarize GLI function in carcinogenesis and cancer-targeted therapy.
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Cite this article as:
Role of Glioma-associated GLI1 Oncogene in Carcinogenesis and Cancertargeted Therapy, Current Cancer Drug Targets 2018; 18 (6) . https://dx.doi.org/10.2174/1568009618666171129223533
DOI https://dx.doi.org/10.2174/1568009618666171129223533 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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