摘要
溶瘤病毒现在有望为癌症提供新的治疗策略。 自1998年以来,其概念引发了这一类产品的商业化研发活动。自1999年以来,由上海双威生物技术有限公司开发的世界上第一个商品化的溶瘤病毒产品Oncorine(H101) 于2005年11月在中国国家食品药品监督管理局通过III期临床试验后获得了鼻咽癌联合化疗的批准,最终于2006年8月获得了GMP证书。本文介绍了Oncorine在中国如何成功开发以及中国市场如何应对 在2006年上市之后。
关键词: Oncorine,溶瘤病毒,鼻咽癌,癌症,化疗,病毒疗法。
图形摘要
Current Cancer Drug Targets
Title:Oncorine, the World First Oncolytic Virus Medicine and its Update in China
Volume: 18 Issue: 2
关键词: Oncorine,溶瘤病毒,鼻咽癌,癌症,化疗,病毒疗法。
摘要: The oncolytic viruses now hold a promise of new therapeutic strategy for cancer. Its concept has inspired a wave of commercial research and development activities for the products of this category in China since 1998. The first commercialized oncolytic virus product in the world, Oncorine (H101), developed by Shanghai Sunway Biotech Co., Ltd since 1999, was approved by Chinese SFDA in November, 2005 for nasopharyngeal carcinoma in combination with chemotherapy after the phase III clinical trial, and finally acquired GMP certificate in August, 2006. This review introduces how Oncorine was successfully developed in China, and how the Chinese market responded after it was launched into the market in 2006.
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Cite this article as:
Oncorine, the World First Oncolytic Virus Medicine and its Update in China, Current Cancer Drug Targets 2018; 18 (2) . https://dx.doi.org/10.2174/1568009618666171129221503
DOI https://dx.doi.org/10.2174/1568009618666171129221503 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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