Recent Advances in Peptide-Based Approaches for Cancer Treatment

doi:10.2174/0929867325666171123204851
摘要

背景：基于肽的药物由于能够填补两大类可用药物，小分子和生物制剂之间的空白，最近经历了复兴。肽结合了大蛋白所具有的高效能和选择性以及小分子的一些特征优势，例如合成的可及性，稳定性和口服生物利用度的潜力。方法：在本文中，我们回顾了有关基于肽的癌症治疗方法的最新文献，重点介绍了每种策略的最新进展，优势和挑战。结果：基于肽的方法迅速发展的应用之一是癌症治疗，重点是新的和既定的靶标。我们以选定的例子来描述最近几年开发的一些新型的基于肽的癌症治疗方法，范围从天然存在的肽和修饰的肽到肽药物偶联物，肽纳米材料和基于肽的疫苗。结论：这篇综述揭示了基于肽的策略在肿瘤学研究中的新兴作用，批判性地分析了这些方法的优点和局限性以及它们作为有效的抗癌疗法的发展潜力。
关键词: 基于肽的癌症治疗剂，抗癌肽，肽-药物结合物，纳米颗粒-肽材料，癌症疫苗，肿瘤靶向。
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DOI https://dx.doi.org/10.2174/0929867325666171123204851	Print ISSN 0929-8673
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