Ganoderma lucidum Polysaccharides as An Anti-cancer Agent

Title:Ganoderma lucidum Polysaccharides as An Anti-cancer Agent

Volume: 18 Issue: 5

Author(s): Didem Sohretoglu and Shile Huang*

Affiliation:

• Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932,United States

Keywords: Ganoderma lucidum polysaccharides, Reishi, anti-cancer, immunomodulatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic.

Abstract: The mushroom Ganoderma lucidum (G. lucidum) has been used for centuries in Asian countries to treat various diseases and to promote health and longevity. Clinical studies have shown beneficial effects of G. lucidum as an alternative adjuvant therapy in cancer patients without obvious toxicity. G. lucidum polysaccharides (GLP) is the main bioactive component in the water soluble extracts of this mushroom. Evidence from in vitro and in vivo studies has demonstrated that GLP possesses potential anticancer activity through immunomodulatory, anti-proliferative, pro-apoptotic, anti-metastatic and anti-angiogenic effects. Here, we briefly summarize these anticancer effects of GLP and the underlying mechanisms.

Cite this article as:

Sohretoglu Didem and Huang Shile*, Ganoderma lucidum Polysaccharides as An Anti-cancer Agent, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (5) . https://dx.doi.org/10.2174/1871520617666171113121246