摘要
背景:发现LAAOs(EC 1.4.3.2)的浓度根据每种蛇的不同而不同; Viperidae,Crotalidae和Elapidae在其毒液中含有1-9%的这种酶。 方法:本综述重点介绍SVLAAOs作用的分子机制,血小板活性,抗菌,抗原生动物,诱导细胞凋亡和炎症潜能的最新进展。 结果:蛇毒LAAO(SV-LAAOs)已成为药理学,结构学和分子学研究的一个有趣课题。 结论:虽然这些酶的作用机制尚不清楚,但它们是各种研究的主题,因为LAAO是多功能酶,具有广泛的药理作用,包括抑制或诱导血小板聚集,溶血和出血,除了刺激细胞凋亡外,白细胞的活化和水肿的形成。此外,SV-LAAO在杀菌,细胞毒性,抗寄生虫,抗肿瘤和抗病毒活性中起重要作用
关键词: 蛇毒,LAAO,作用机制,生物医学潜力,聚集,细胞凋亡,杀微生物,炎症。
Current Medicinal Chemistry
Title:An Update on Potential Molecular Mechanisms Underlying the Actions of Snake Venom L-amino Acid Oxidases (LAAOs)
Volume: 25 Issue: 21
关键词: 蛇毒,LAAO,作用机制,生物医学潜力,聚集,细胞凋亡,杀微生物,炎症。
摘要: Background: LAAOs (EC 1.4.3.2) are found in concentrations that vary according to each species of snakes; Viperidae, Crotalidae and Elapidae contain 1-9% of this enzyme in their venoms.
Methods: This review focuses on an update on molecular mechanisms, platelet activities, antimicrobial, antiprotozoal, induction of apoptosis and inflammatory potential underlying the actions of SVLAAOs.
Results: Snake venom LAAOs (SV-LAAOs) have become an interesting subject for pharmacological, structural and molecular studies.
Conclusion: Although the mechanisms of action of these enzymes are not well understood they are a subject of a variety of studies, because LAAOs are multifunctional enzymes exhibiting a wide range of pharmacological effects, including the inhibition or induction of platelet aggregation, hemolysis and hemorrhage, in addition to the stimulation of apoptosis, the activation of leukocytes and the formation of edema.
Moreover, SV-LAAOs play an important role in bactericidal, cytotoxic, anti-parasitic, anti-tumor, and antiviral activities.
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Cite this article as:
An Update on Potential Molecular Mechanisms Underlying the Actions of Snake Venom L-amino Acid Oxidases (LAAOs), Current Medicinal Chemistry 2018; 25 (21) . https://dx.doi.org/10.2174/0929867324666171109114125
DOI https://dx.doi.org/10.2174/0929867324666171109114125 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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