摘要
抗菌药物耐药性的惊人增加导致越来越多的研究旨在开发新的抗菌药物疗法。天然抗菌肽具有很强的广泛性。果胶抗菌活性与多种独特的结构单元结合在一起,赋予了它们不同的作用机制。这些肽在生物体中普遍存在,是先天免疫系统。近年来,海洋甲壳动物抗菌肽的鉴定已成为许多研究者关注的焦点。这种日益增长的兴趣源于这句话。这些肽的结构和遗传组成与陆地上的肽相比具有多样性。因此,海洋甲壳动物的多肽可以作为新的抗icr的模板。间谍。本文综述了海洋甲壳类抗菌肽的种类、抗菌活性及其结构活性关系。我们还讨论了以及它们作为新抗菌剂的发展挑战。
关键词: 抗菌活性,结构-活性关系,抗菌肽,作用机制,海洋肽,甲壳类。
Current Medicinal Chemistry
Title:Antimicrobial Peptides of Marine Crustaceans: The Potential and Challenges of Developing Therapeutic Agents
Volume: 25 Issue: 19
关键词: 抗菌活性,结构-活性关系,抗菌肽,作用机制,海洋肽,甲壳类。
摘要: The alarming increase of antimicrobial resistance has led to a growing number of studies aiming to develop novel antimicrobial therapeutics. Natural antimicrobial peptides possess a potent and broad-spectrum antimicrobial activity combined with diverse and unique structural motifs, which confer their different mechanisms of action. These peptides are ubiquitous in organisms and are integral to the innate immune system. Recently, identification of antimicrobial peptides from marine crustaceans has become the centre of attention of many researchers. This increasing interest stems from the remarkable diversity in the structural and genetic composition of these peptides compared to terrestrial counterparts. Thus, peptides from marine crustaceans can serve as future templates for novel antimicrobial agents. Here, we provide an overview of various antimicrobial peptides from the marine crustaceans, their antimicrobial activity and structure- activity relationships. We also discuss the potential and challenges of their development as new antimicrobial agents.
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Cite this article as:
Antimicrobial Peptides of Marine Crustaceans: The Potential and Challenges of Developing Therapeutic Agents, Current Medicinal Chemistry 2018; 25 (19) . https://dx.doi.org/10.2174/0929867324666171106155936
DOI https://dx.doi.org/10.2174/0929867324666171106155936 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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