摘要
背景:胃癌是一种全球死亡率高的恶性肿瘤。不良临床症状,不良预后和缺乏适当诊断技术用于早期发现会导致许多患者死亡。为GC的早期检测和进展而存在的新的敏感和特异性生物标志物可以降低死亡率。除了细胞内的miRNA之外,循环miRNA还反映了癌症进展的状态,并且可能是用于GC中快速检测和治疗的潜在生物标志物。 目的:在简要说明循环miRNA及其各种类型之后,我们综合回顾了最近一些将循环miRNA作为GC诊断/预后生物标志物的研究。 方法:总结PubMed和Scopus数据库中的研究和综述文章。主要使用的关键词与循环miRNA有关,并且它们在胃癌中的诊断和预后价值。在许多循环miRNA中,根据其重复性,特异性和敏感性进行比较。 结果:比较表明,与其他检测方法相比,循环miRNA具有高灵敏度和特异性的高诊断价值。大量循环miRNA的表达水平改变与临床病理因素之间也存在关联,并且也与GC治疗中的反应有关。 结论:循环miRNA作为检测生物标志物的优势已经引起了广泛的研究并取得了重大进展。循环miRNA的表达模式改变与GC组织的病理状态有关,其独特的特征使其成为GC的理想早期诊断,预后和预测性生物标志物。
关键词: 循环miRNA,胃癌,生物标志物,诊断,预后,外泌体
Current Medicinal Chemistry
Title:Circulating MicroRNAs: Valuable Biomarkers for the Diagnosis and Prognosis of Gastric Cancer
Volume: 25 Issue: 6
关键词: 循环miRNA,胃癌,生物标志物,诊断,预后,外泌体
摘要: Background: Gastric cancer is a malignancy with high mortality rate worldwide. Poor clinical symptoms, unfavorable prognosis and absence of proper diagnostic techniques for early detection cause death in many patients. Presence of new sensitive and specific biomarkers for early detection and progression of GC could lead to reduction in the mortality rate. In addition to intracellular miRNAs, circulating miRNAs reflect the state of cancer progression and might be potential biomarkers for rapid detection and also therapy in GC.
Objective: After giving a brief explanation about circulating miRNAs and their various types, we then reviewed comprehensively the last studies which investigated circulating miRNAs as diagnostic/prognostic biomarkers in GC.
Methods: Research and review articles in PubMed and Scopus databases were summarized. Keywords mainly used were in related to circulating miRNAs and their diagnostic and prognostic value in gastric cancer. Among the numerous circulating miRNAs a comparison was made based on their repeatability, specificity and sensitivity.
Results: Comparisons indicated high diagnostic value of circulating miRNAs in comparison with other detection methods based on their high sensitivity and specificity. There was also a relation between altered expression level of large number of circulating miRNAs and clinicopathological factors and also response to therapy in GC.
Conclusion: Several advantages of circulating miRNAs as detection biomarker have led to extensive studies and significant advances. Altered expression pattern of circulating miRNAs have correlation with pathological status of GC tissues and their exclusive features make them ideal early diagnostic, prognostic and predictive biomarkers for GC.
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Circulating MicroRNAs: Valuable Biomarkers for the Diagnosis and Prognosis of Gastric Cancer, Current Medicinal Chemistry 2018; 25 (6) . https://dx.doi.org/10.2174/0929867324666171003123425
DOI https://dx.doi.org/10.2174/0929867324666171003123425 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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