摘要
类黄酮是植物性食物的主要饮食成分,在植物界普遍存在,它们通常以大量存在。芦丁是一种黄酮醇型多酚,由黄酮醇槲皮素和二糖芸香糖组成。据报道,芦丁具有多种生物学作用,例如主要与抗氧化剂和抗炎活性有关的抗肿瘤和抗菌作用。精神,神经和行为障碍是发病率的重要且不断增长的原因。这些疾病大多数都具有较高的患病率,早期发作,进行性临床病程以及严重的脑功能受损,使其成为造成全球疾病负担的主要因素。在当前的工作中,综述了芦丁在神经退行性过程中的生物学,体外和体内作用以及潜在的治疗应用,以及它们的生物利用度和药代动力学,这对于更好地了解其生物学有效性至关重要。此外,本综述还概述了芦丁通过其发挥神经保护作用的分子机制。
关键词: 阿尔茨海默氏病,抗氧化剂,类黄酮,神经退行性疾病,多酚,芦丁。
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