摘要
背景：配位化学在纳米技术中的应用是一个快速发展的医学研究领域。铋配合物已广泛用于生物医学中，具有令人满意的治疗效果，主要用于根除幽门螺杆菌，但也作为潜在的抗微生物和抗利什曼药物。另外，近年来，已经广泛研究了铋基化合物作为有效抗癌药物的应用。 方法：使用基于网络的文献检索工具，如ScienceDirect，Springer，皇家化学学会，美国化学学会和Wiley，搜索与癌症化学和放射治疗中铋化合物的最新趋势相关的数据。相关文献涵盖到2016年。 结果：在本综述中，基于213篇论文，我们强调了许多与当前相关的问题：（i）用选定的缩氨基硫脲，腙和二硫代氨基甲酸酯类配体作为潜在的化学治疗剂来表征铋络合物。来自50篇论文的文献结果表明，几乎所有的铋化合物都能抑制乳腺癌，结肠癌，卵巢癌，肺癌和其他肿瘤的生长和增殖。 （ii）应用基于铋的纳米粒子和纳米点进行放射增敏的开创性研究。结果显示，在先进放疗中电离辐射的治疗效果有很大提升（36篇论文中有描述）; （iii）在靶向放射免疫疗法中使用铋放射性核素的研究挑战，与选择适当的放射性核素，靶向载体，适当的双功能配体和213Bi反冲子体毒性问题有关（来自92篇论文）。 结论：本综述介绍了癌症化学和放射治疗中铋化合物的最新研究趋势，为未来的研究提供了方向。
关键词: 铋（III）配合物，抗癌特性，化学治疗剂，Bi基纳米粒子，放射治疗，213Biα靶向放射免疫疗法。
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